Evidence map›Paper›PMID 34909434›Full record

ArticleISRN biomedical engineering2013

Extrahepatic 25-Hydroxylation of Vitamin D

Shelley S Mason, Sean S Kohles, Shelley R Winn, Randy D Zelick

Open access · hybridAbstract read
In one paragraph

Article in ISRN biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Shelley S MasonDepartment of Biology, Portland State University, P.O. Box 751, Portland, OR 97207-0751, USA.
Sean S KohlesDepartment of Biology, Portland State University, P.O. Box 751, Portland, OR 97207-0751, USA.
Shelley R WinnDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA.
Randy D ZelickDepartment of Biology, Portland State University, P.O. Box 751, Portland, OR 97207-0751, USA.
Portland State University · USOregon Health & Science University · US

Funding

Research TechnologyP20MD003350 · NIMHD · CENTRAL STATE UNIV (WILBERFORCE, OH) · PI JACKSONHAMMOND, CYNTHIA · 2008 to 2012
$4.2M
Multiaxial Single-Cell Biomechanics for MechanotransductionR15EB007077 · NIBIB · PORTLAND STATE UNIVERSITY · PI KOHLES, SEAN S · 2007 to 2007
$219k
NIBIB NIH HHS R15 EB007077NIMHD NIH HHS P20 MD003350
6 · The paper itself

Abstract

Osteoblastic precursors experience distinct stages during differentiation and bone development, which include proliferation, extracellular matrix (ECM) maturation, and ECM mineralization. It is well known that vitamin D plays a large role in the regulation of bone mineralization and homeostasis via the endocrine system. The activation of vitamin D requires two sequential hydroxylation steps, first in the kidney and then in the liver, in order to carry out its role in calcium homeostasis. Recent research has demonstrated that human-derived mesenchymal stem cells (MSCs) and osteoblasts can metabolize the immediate vitamin D precursor 25-dihydroxyvitamin D

Identifiers

PMID34909434
PMCPMC8667671
OpenAlexW1996025468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.