Evidence map›Paper›PMID 34909400›Full record

ArticleWorld journal of clinical oncology2021

Modulated electro-hyperthermia in stage III and IV pancreatic cancer: Results of an observational study on 158 patients.

Giammaria Fiorentini, Donatella Sarti, Girolamo Ranieri, Cosmo Damiano Gadaleta, Caterina Fiorentini, Carlo Milandri, Andrea Mambrini, Stefano Guadagni

Open access · diamondAbstract read
In one paragraph

Article in World journal of clinical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Hyperthermia combined with chemotherapyWorld journal of clinical oncology · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Giammaria FiorentiniDepartment of Onco-Hematology, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", Pesaro 61122, Italy. g.fiorentini2020@gmail.com.
Donatella SartiOncology Department, Ospedale S. Maria Della Misericordia, ASUR1, Urbino 61029, Italy.
Girolamo RanieriInterventional and Integrated Medical Oncology, National Cancer Research Centre, IRCCS Istituto Tumori "Giovanni Paolo II", Bari 70124, Italy.
Cosmo Damiano GadaletaInterventional and Integrated Medical Oncology, National Cancer Research Centre, IRCCS Istituto Tumori "Giovanni Paolo II", Bari 70124, Italy.
Caterina FiorentiniDepartment of Medical Biothecnologies, Division of Cardiology, University Hospital of Siena, Siena 53100, Italy.
Carlo MilandriMedical Oncology Unit, San Donato Hospital, Arezzo 52100, Italy.
Andrea MambriniDepartment of Oncology - ASL Toscana Nord Ovest, Massa Carrara Hospital, Massa 54100, Italy.
Stefano GuadagniApplied Clinical Sciences and Biotechnology, Section of General Surgery, University of L'Aquila, L'Aquila 67100, Italy.
Ospedale San Donato · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn increasing number of studies report the beneficial effects of regional hyperthermia in association with chemotherapy (CHT) and radiotherapy for the treatment of pancreatic cancer; in particular, the use of modulated electro-hyperthermia (mEHT) results in increased survival and tumor response.

aimTo compare outcomes of CHT alone or in association with mEHT for the treatment of stage III and IV pancreatic cancer.

methodsThis was an observational retrospective study; data were collected for patients with stage III-IV pancreatic cancer that were treated with CHT alone or in combination with mEHT from 2003 to 2019. A total of 158 patients were included in the study out 270 patients screened in four Italian hospitals; 58 (37%) of these received CHT + mEHT and 100 (63%) CHT. CHT was mainly gemcitabine-based regimens in both groups.

resultsOverall (19.5 mo

conclusionThe addition of mEHT to systemic CHT improved overall and progression-free survival and local tumor control with comparable toxicity.

Indexed as

Locally advanced pancreatic cancerModulated electro-hyperthermiaSurvivalTumor response

Identifiers

PMID34909400
PMCPMC8641006
OpenAlexW3217293751

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.