ReviewEFORT open reviews2021
Higher rates of surgical and medical complications and mortality following TKA in patients aged ≥ 80 years: a systematic review of comparative studies.
Review in EFORT open reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optimal inputs for machine learning models in predicting total joint arthroplasty outcomes: a systematic review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Pooled it
- Trial
- The Effects of Pedaling-Based Progressive Resistance Training on Range of Motion, Muscle Strength, and Physical Function in Female Patients with Total Knee Arthroplasty: Single-Blind Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2025Trial
- Younger age doubles medium-term revision risk after total knee arthroplasty: A nationwide multicenter cohort of 5980 knees from the French SCORE I registry.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Association Between Multimorbidity and Walking Independence After Total Knee Arthroplasty in Adults Aged ≥80 Years: A Retrospective Cohort Study.Geriatric orthopaedic surgery & rehabilitation · 2026Article
- Determinants of effectiveness in orthopedic ERAS: a cross-setting perspective based on the integration of nutritional status and clinical outcomes.Frontiers in nutrition · 2026Article
- Pooling data for primary total knee implants across national registries: is the same implant used in multiple registries and for the same patient group? An observational study.Acta orthopaedica · 2025Observational
- Preoperative Physical Factors Predictive of Clinical Outcomes after Total Knee Arthroplasty.Progress in rehabilitation medicine · 2025Article
- Factors influencing the decision to receive total knee replacement among patients with severe knee osteoarthritis under universal health insurance coverage.Scientific reports · 2024Article
- Patient experiences with a smartphone application dedicated to postoperative recovery after elective arthroplasty.Journal of clinical orthopaedics and trauma · 2024Article
- Effect of low-intensity muscle strength training on postoperative rehabilitation and adverse events in patients with knee osteoarthritis over 55 years of age: a meta-analysis.BMC sports science, medicine & rehabilitation · 2024Article
- Progress in Computer-Assisted Navigation for Total Knee Arthroplasty in Treating Knee Osteoarthritis with Extra-Articular Deformity.Orthopaedic surgery · 2024Review
- The Impact of Tranexamic Acid on Blood Loss Management in Primary Total Knee Arthroplasty: A Comprehensive Review.Cureus · 2024Review
- Similar survival rate but lower functional outcomes following TKA in the elderly people compared to younger patients: analysis of a posterior stabilised implant with minimum 5-year follow-up.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Article
- Development and validation of a nomogram to predict complications in patients undergoing simultaneous bilateral total knee arthroplasty: A retrospective study from two centers.Frontiers in surgery · 2022Article
- Rate of complications with hip and knee arthroplasties performed at a private hospital in Canada.Canadian journal of surgery. Journal canadien de chirurgieArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this systematic review was to synthesize studies published since the last systematic review in 2015 that compare outcomes of primary total knee arthroplasty (TKA) in older patients (≥ 80 years) and in younger patients (< 80 years), in terms of complication rates and mortality.An electronic literature search was conducted using PubMed, Embase®, and Cochrane Register. Studies were included if they compared outcomes of primary TKA for osteoarthritis in patients aged 80 years and over to patients aged under 80 years, in terms of complication rates, mortality, or patient-reported outcomes (PROs).Thirteen studies were eligible. Surgical complications in older patients ranged from 0.6-21.1%, while in younger patients they ranged from 0.3-14.6%. Wound complications in older patients ranged from 0.5-20%, while in younger patients they ranged from 0.8-22.0%. Medical complications (cardiac, respiratory, thromboembolic) in older patients ranged from 0.4-17.3%, while in younger patients they ranged from 0.2-11.5%.Mortality within 90 days in older patients ranged between 0-2%, while in younger patients it ranged between 0.0-0.03%.Compared to younger patients, older patients have higher rates of surgical and medical complications, as well as higher mortality following TKA. The literature also reports greater length of stay for older patients, but inconsistent findings regarding PROs. The present findings provide surgeons and older patients with clearer updated evidence, to make informed decisions regarding TKA, considering the risks and benefits within this age group. Patients aged over 80 years should therefore not be excluded from consideration for primary TKA based on age alone. Cite this article:
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.