Evidence map›Paper›PMID 34909146›Full record

ArticleChemical science2021

Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines.

Mingxu Li, Jian Zhang, Yashi Zou, Fengfan Zhou, Zhenfeng Zhang, Wanbin Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mingxu LiShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China zhenfeng@sjtu.edu.cn.
Jian ZhangShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China zhenfeng@sjtu.edu.cn.
Yashi ZouShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China zhenfeng@sjtu.edu.cn.
Fengfan ZhouShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China zhenfeng@sjtu.edu.cn.
Zhenfeng ZhangShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China zhenfeng@sjtu.edu.cn.ORCID https://orcid.org/0000-0003-3295-6966
Wanbin ZhangShanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China zhenfeng@sjtu.edu.cn.ORCID https://orcid.org/0000-0002-4788-4195

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asymmetric hydrogenation of unsaturated morpholines has been developed by using a bisphosphine-rhodium catalyst bearing a large bite angle. With this approach, a variety of 2-substituted chiral morpholines could be obtained in quantitative yields and with excellent enantioselectivities (up to 99% ee). The hydrogenated products could be transformed into key intermediates for bioactive compounds.

Identifiers

PMID34909146
PMCPMC8612400

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.