Evidence map›Paper›PMID 34909131›Full record

ArticleNutrition research and practice2021

25-Hydroxyvitamin D level is associated with mortality in patients with critical COVID-19: a prospective observational study in Mexico City.

Israel Parra-Ortega, Diana Guadalupe Alcara-Ramírez, Alma Angélica Ronzon-Ronzon, Fermín Elías-García, José Agustín Mata-Chapol, Alejandro Daniel Cervantes-Cote, Briceida López-Martínez, Miguel Angel Villasis-Keever, Jessie Nallely Zurita-Cruz

Open access · diamondAbstract read
In one paragraph

Article in Nutrition research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. The effects of SARS-CoV-2 on bone homeostasis.Frontiers in endocrinology · 2026
    Review
  2. Review
  3. Low Vitamin D Levels Are Associated With Long COVID Syndrome in COVID-19 Survivors.The Journal of clinical endocrinology and metabolism · 2023
    Article
  4. Article
  5. Long-term implications of COVID-19 on bone health: pathophysiology and therapeutics.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Israel Parra-OrtegaAuxiliary Diagnostic Services, Hospital Infantil de México Federico Gómez, Ministry of Health (SSA), Mexico City 06720, Mexico.ORCID https://orcid.org/0000-0002-7195-1749
Diana Guadalupe Alcara-RamírezAuxiliary Diagnostic Services, Hospital Infantil de México Federico Gómez, Ministry of Health (SSA), Mexico City 06720, Mexico.ORCID https://orcid.org/0000-0003-1394-5751
Alma Angélica Ronzon-RonzonRadiology and Imaging Service, General Zone Hospital 48, Instituto Mexicano del Seguro Social, Mexico City 02750, Mexico.ORCID https://orcid.org/0000-0001-9373-9290
Fermín Elías-GarcíaAuxiliary Diagnostic Services, Hospital Infantil de México Federico Gómez, Ministry of Health (SSA), Mexico City 06720, Mexico.ORCID https://orcid.org/0000-0002-9158-5053
José Agustín Mata-ChapolAuxiliary Diagnostic Services, General Zone Hospital 48, Instituto Mexicano del Seguro Social, Mexico City 02750, Mexico.ORCID https://orcid.org/0000-0002-0056-0767
Alejandro Daniel Cervantes-CoteAuxiliary Diagnostic Services, General Zone Hospital 48, Instituto Mexicano del Seguro Social, Mexico City 02750, Mexico.ORCID https://orcid.org/0000-0002-2622-7604
Briceida López-MartínezAuxiliary Diagnostic Services, Hospital Infantil de México Federico Gómez, Ministry of Health (SSA), Mexico City 06720, Mexico.ORCID https://orcid.org/0000-0002-6081-5602
Miguel Angel Villasis-KeeverAnalysis and Synthesis of the Evidence Research Unit, National Medical Center XXI Century, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico.ORCID https://orcid.org/0000-0002-8566-0811
Jessie Nallely Zurita-CruzFacultad de Medicina Universidad Nacional Autónoma de México, Hospital Infantil de México Federico Gómez, Mexico City 06720, Mexico.ORCID https://orcid.org/0000-0003-1389-7964
Hospital Infantil de México Federico Gómez · MXMexican Social Security Institute · MXHospital General De Zona · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesConsidering the high number of deaths from coronavirus disease 2019 (COVID-19) in Latin American countries, together with multiple factors that increase the prevalence of vitamin D deficiency, we aimed to determine 25-hydroxyvitamin D (25[OH]D) levels and its association with mortality in patients with critical COVID-19. SUBJECTS/

methodsThis was a prospective observational study including adult patients with critical COVID-19. Data, including clinical characteristics and 25(OH)D levels measured at the time of intensive care unit admission, were collected. All patients were followed until hospital discharge or in-hospital death. The patients were divided into those surviving and deceased patient groups, and univariate and multivariate logistic regression analyses were performed to determine independent predictors of in hospital mortality.

resultsThe entire cohort comprised 94 patients with critical COVID-19 (males, 59.6%; median age, 61.5 years). The median 25(OH)D level was 12.7 ng/mL, and 15 (16%) and 79 (84%) patients had vitamin D insufficiency and vitamin D deficiency, respectively. The median serum 25(OH)D level was significantly lower in deceased patients compared with surviving (12.1 vs. 18.7 ng/mL,

conclusionsVitamin D deficiency was present in 84% of critical COVID-19 patients. Serum 25(OH)D was independently associated with mortality in critical patients with COVID-19.

Indexed as

COVID-19critical illnessmortalitySARS-CoV-2 virusVitamin D

Identifiers

PMID34909131
PMCPMC8636388
OpenAlexW3202953683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.