Evidence map›Paper›PMID 34909070›Full record

ArticleThe Pan African medical journal2021

Adverse events following immunization reporting and impact on immunization services in informal settlements in Nairobi, Kenya: a prospective mixed-methods study.

Oliver Ombeva Malande, Deogratias Munube, Rachel Nakatugga Afaayo, Carolyne Chemweno, Mutunga Nzoka, James Kipsang, Andrew Munyalo Musyoki, Johanna Catharina Meyer, Leonidah Nyamusi Omayo, Lawrence Owino-Okongo

Open access · greenAbstract read
In one paragraph

Article in The Pan African medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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  11. RTS,S/AS01Malaria journal · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Oliver Ombeva MalandeEast Africa Centre for Vaccines and Immunization, Administration Department Kampala, Kampala, Uganda.
Deogratias MunubeEast Africa Centre for Vaccines and Immunization, Administration Department Kampala, Kampala, Uganda.
Rachel Nakatugga AfaayoEast Africa Centre for Vaccines and Immunization, Administration Department Kampala, Kampala, Uganda.
Carolyne ChemwenoEast Africa Centre for Vaccines and Immunization, Administration Department Kampala, Kampala, Uganda.
Mutunga NzokaEast Africa Centre for Vaccines and Immunization, Administration Department Kampala, Kampala, Uganda.
James KipsangEast Africa Centre for Vaccines and Immunization, Administration Department Kampala, Kampala, Uganda.
Andrew Munyalo MusyokiDepartment of Microbiological Pathology, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Johanna Catharina MeyerDivision of Public Health Pharmacy, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Leonidah Nyamusi OmayoEast Africa Centre for Vaccines and Immunization, Administration Department Kampala, Kampala, Uganda.
Lawrence Owino-OkongoEast Africa Centre for Vaccines and Immunization, Administration Department Kampala, Kampala, Uganda.
Makerere University · UGSefako Makgatho Health Sciences University · ZAUniversity of Nairobi · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionadverse events following immunization (AEFIs) are thought to contribute to cases of vaccine hesitancy, yet little data exists describing the state of reporting and management of AEFIs. This study investigated the occurrence and influence of AEFIs on vaccine hesitancy in an informal settlement of Nairobi.

methodsthis was a prospective mixed-methods study involving 7 focus group discussions, 8 key informant interviews and 457 face-to-face interviews with caregivers. Caregivers were recruited at/or before the 6 week clinic visit and assessed for occurrence of AEFIs in their children at the subsequent 10- and 14-week visits and a follow-up two weeks following the 14 weeks visit via phone calls.

resultsin this study, 12.3% (56/457) of the infants experienced an AEFI. Of these, 19 did not report for the next scheduled vaccine. Fever was the most common AEFI, for which most caregivers (66.7%) used Paracetamol as antipyretic, while 20.8% sought help from a nearby health facility. Three of the 56 AEFIs (convulsions) that occurred in study participants could be classified as severe reactions. Diphtheria, pertussis and tetanus (DPT 3) completion rate was 75.3%. Most (96.4%) caregivers considered immunization an important strategy for child survival. Vaccine hesitancy occurred among 3.6% of participants, 30% of whom attributed their hesitancy to occurrence of AEFIs. The review of health records revealed that no AEFI had been reported from any of the study facilities.

conclusioncases of adverse events following immunization are not reported in Mathare Valley and they do have implications for vaccine hesitancy by some caregivers.

Indexed as

Adverse Drug Reaction Reporting SystemsVaccination HesitancyChildHumansImmunizationInfantKenyaProspective StudiesVaccinationchildfocus groupsimmunization programsinformal settlementsKenyaVaccination

Identifiers

PMID34909070
PMCPMC8607951
OpenAlexW3210911217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.