Evidence map›Paper›PMID 34908940›Full record

ArticleClinical neuropsychiatry2019

Maladaptive Coping Strategies and Neuroticism Mediate the Relationship Between 5HTT-LPR Polymorphisms and Symptoms of Anxiety in Elite Athletes.

Mario Altamura, Salvatore Iuso, Giovanna D'Andrea, Francesca D'Urso, Carla Piccininni, Eleonora Angelini, Francesco Sessa, Maurizio Margaglione, Caterina Padulo, Beth Fairfield and 2 more

Open access · greenAbstract read
In one paragraph

Article in Clinical neuropsychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The Athlete's Paradox: Adaptable Depression.Sports (Basel, Switzerland) · 2022
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  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Mario AltamuraDepartment of Clinical and Experimental Medicine, Psychiatry Unit, University of Foggia, Foggia, Italy.
Salvatore IusoDepartment of Clinical and Experimental Medicine, Psychiatry Unit, University of Foggia, Foggia, Italy.
Giovanna D'AndreaDepartment of Clinical and Experimental Medicine, Medical Genetics, University of Foggia, Foggia, Italy.
Francesca D'UrsoDepartment of Clinical and Experimental Medicine, Psychiatry Unit, University of Foggia, Foggia, Italy.
Carla PiccininniDepartment of Clinical and Experimental Medicine, Psychiatry Unit, University of Foggia, Foggia, Italy.
Eleonora AngeliniDepartment of Clinical and Experimental Medicine, Psychiatry Unit, University of Foggia, Foggia, Italy.
Francesco SessaDepartment of Clinical and Experimental Medicine, Medical Genetics, University of Foggia, Foggia, Italy.
Maurizio MargaglioneDepartment of Clinical and Experimental Medicine, Medical Genetics, University of Foggia, Foggia, Italy.
Caterina PaduloDepartment of Psychological, Health and Territorial Sciences, University of Chieti, Italy.
Beth FairfieldDepartment of Psychological, Health and Territorial Sciences, University of Chieti, Italy.
Annamaria PetitoDepartment of Clinical and Experimental Medicine, Psychiatry Unit, University of Foggia, Foggia, Italy.
Antonello BellomoDepartment of Clinical and Experimental Medicine, Psychiatry Unit, University of Foggia, Foggia, Italy.
University of Foggia · ITUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePrevious studies have suggested that genetic factors, personality traits and coping strategies might play both independent and interacting roles when influencing stress-related anxiety symptoms. The aim of this study was to examine whether Neuroticism and maladaptive coping strategies mediate the association between the serotonin transporter gene-linked polymorphic region (5HTT-LPR) and symptoms of anxiety and depression in elite athletes who experience high levels of competitive stress.

methodOne hundred and thirty-three participants were genotyped for the 5-HTTLPR polymorphism and then asked to complete the Cope Orientation to Problems Experienced Inventory and the NEO Five-Factor Inventory. A path analysis was used to test this hypothesis.

resultsThe 5HTT-LPR was significantly associated with Neuroticism, the coping strategy of Focus on and Venting of Emotions' (FVE) and symptoms of anxiety. FVE and Neuroticism mediated the association between the 5HTT-LPR and symptoms of anxiety (i.e., Cognitive Anxiety and Emotional Arousal Control). Also, Neuroticism was a mediator of the association between the 5HTT-LPR and FVE. Finally, FVE also mediated effects on the relationship between Neuroticism and symptoms of anxiety.

conclusionsThe 5HTT-LPR may affect the susceptibility to develop symptoms of anxiety in elite athletes indirectly through mediation by maladaptive coping strategies and Neuroticism.

Indexed as

5HTT-LPRanxietycopingelite athletesmediation analysisneuroticism

Identifiers

PMID34908940
PMCPMC8650181
OpenAlexW2904947213

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.