Evidence map›Paper›PMID 34908928›Full record

ArticleJournal of geriatric cardiology : JGC2021

Biomarkers in the clinical management of patients with atrial fibrillation and heart failure.

Ioanna Koniari, Eleni Artopoulou, Dimitrios Velissaris, Mark Ainslie, Virginia Mplani, Georgia Karavasili, Nicholas Kounis, Grigorios Tsigkas

Open access · greenAbstract read
In one paragraph

Article in Journal of geriatric cardiology : JGC, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ioanna KoniariManchester Heart Institute, Manchester University Foundation Trust, Manchester, United Kingdom.
Eleni ArtopoulouDepartment of Internal Medicine, University Hospital of Patras, Patras, Greece.
Dimitrios VelissarisDepartment of Internal Medicine, University Hospital of Patras, Patras, Greece.
Mark AinslieManchester Heart Institute, Manchester University Foundation Trust, Manchester, United Kingdom.
Virginia MplaniDepartment of Cardiology, University Hospital of Patras, Patras, Greece.
Georgia KaravasiliManchester Heart Institute, Manchester University Foundation Trust, Manchester, United Kingdom.
Nicholas KounisDepartment of Cardiology, University Hospital of Patras, Patras, Greece.
Grigorios TsigkasDepartment of Cardiology, University Hospital of Patras, Patras, Greece.
General University Hospital of Patras · GRUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) and heart failure (HF) are two cardiovascular diseases with an increasing prevalence worldwide. These conditions share common pathophysiologiesand frequently co-exit. In fact, the occurrence of either condition can 'cause' the development of the other, creating a new patient group that demands different management strategies to that if they occur in isolation. Regardless of the temproral association of the two conditions, their presence is linked with adverse cardiovascular outcomes, increased rate of hospitalizations, and increased economic burden on healthcare systems. The use of low-cost, easily accessible and applicable biomarkers may hasten the correct diagnosis and the effective treatment of AF and HF. Both AF and HF effect multiple physiological pathways and thus a great number of biomarkers can be measured that potentially give the clinician important diagnostic and prognostic information. These will then guide patient centred therapeutic management. The current biomarkers that offer potential for guiding therapy, focus on the physiological pathways of miRNA, myocardial stretch and injury, oxidative stress, inflammation, fibrosis, coagulation and renal impairment. Each of these has different utility in current clinincal practice.

Identifiers

PMID34908928
PMCPMC8648548
OpenAlexW3215934207

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.