Evidence map›Paper›PMID 34908525›Full record

ArticleeLife2021

Biallelic mutations in

Beibei Wu, Laura Rice, Jennifer Shrimpton, Dylan Lawless, Kieran Walker, Clive Carter, Lynn McKeown, Rashida Anwar, Gina M Doody, Sonal Srikanth and 2 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. RNA-seq analysis reveals transcriptome changes in livers fromBiochemistry and biophysics reports · 2025
    Article
  3. Article
  4. Article
  5. A pleiotropic recurrent dominantScience advances · 2024
    Article
  6. Article
  7. Endosome Traffic Modulates Pro-Inflammatory Signal Transduction in CD4International journal of molecular sciences · 2023
    Review
  8. Article
  9. Metabolic Reprogramming During B-Cell Differentiation.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Beibei Wu *Department of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, United States.ORCID 0000-0002-0784-0745
Laura Rice *Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Jennifer ShrimptonDivision of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.ORCID 0000-0002-6346-6516
Dylan LawlessGlobal Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0001-8496-3725
Kieran WalkerDivision of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.ORCID 0000-0002-6694-2979
Clive CarterDepartment of Clinical Immunology and Allergy, St James's University Hospital, Leeds, United Kingdom.
Lynn McKeownLeeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom.
Rashida AnwarLeeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Gina M DoodyDivision of Haematology and Immunology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Sonal SrikanthDepartment of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, United States.
Yousang Gwack *Department of Physiology, David Geffen School of Medicine, UCLA, Los Angeles, United States.
Sinisa Savic *Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, United Kingdom.ORCID 0000-0001-7910-0554
University of Leeds · GBUniversity of California, Los Angeles · USSt James's University Hospital · GBÉcole Polytechnique Fédérale de Lausanne · CH

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KITCHEN, SCOTT G · 1991 to 2018
$39.9M
Novel regulators of store-operated Ca2+ entry in immune systemsR01AI083432 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2009 to 2020
$3.8M
Mechanism underlying regulation of Ca2+ signaling in local effector T cellsR01AI146615 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2020 to 2024
$1.8M
Distinctive role of ORAI3 channels in the effector T cell responseR21AI149236 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2020 to 2021
$429k
Role of Orai1 trafficking in local effector T cell responsesR56AI146615 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2019 to 2019
$390k
Development of an animal model of severe neutrophilic asthmaR03AI147063 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GWACK, YOUSANG · 2019 to 2020
$156k
Medical Research Council MR/T004134/1NCI NIH HHS P30 CA016042NIAID NIH HHS P30 AI028697NIAID NIH HHS R01 AI083432NIAID NIH HHS R01 AI146615NIAID NIH HHS R03 AI147063NIAID NIH HHS R21 AI149236NIAID NIH HHS R56 AI146615NIH HHS AI083432NIH HHS AI146615NIH HHS AI147063NIH HHS AI149236
6 · The paper itself

Abstract

CRAC channel regulator 2 A (CRACR2A) is a large Rab GTPase that is expressed abundantly in T cells and acts as a signal transmitter between T cell receptor stimulation and activation of the Ca

Indexed as

MutationAdultAsian PeopleCalcium Release Activated Calcium ChannelsCytokinesGenetic VariationHumansPrimary Immunodeficiency DiseasesReceptors, Antigen, T-CellCalcium Release Activated Calcium ChannelsCytokinesReceptors, Antigen, T-CellCRACR2AhumanimmunodeficiencyimmunologyinflammationT cells

Identifiers

PMID34908525
PMCPMC8673834
OpenAlexW4200218595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.