Evidence map›Paper›PMID 34908468›Full record

ArticleMicrobiology spectrum2021

Group B Streptococcus CAMP Factor Does Not Contribute to Interactions with the Vaginal Epithelium and Is Dispensable for Vaginal Colonization in Mice.

Mallory B Ballard, Vicki Mercado-Evans, Madelynn G Marunde, Hephzibah Nwanosike, Jacob Zulk, Kathryn A Patras

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. CAMP-negative group B Streptococcus in pregnant women: molecular and clinical features with implications for diagnostics and neonatal management.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mallory B BallardDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Vicki Mercado-EvansDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Madelynn G MarundeDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Hephzibah NwanosikeDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Jacob ZulkDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Kathryn A PatrasDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.ORCID 0000-0003-2631-8810
Baylor College of Medicine · US

Funding

The Clinical Translational Research Certificate of Added Qualification ProgramT32GM136554 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Melissa Suter, IGNATIA B VAN DEN VEYVER · 2020 to 2026
$3.0M
NIGMS NIH HHS T32 GM136554
6 · The paper itself

Abstract

The Gram-positive pathogen group B Streptococcus (GBS) is a leading cause of neonatal bacterial infections, preterm birth, and stillbirth. Although maternal GBS vaginal colonization is a risk factor for GBS-associated adverse birth outcomes, mechanisms promoting GBS vaginal persistence are not fully defined. GBS possesses a broadly conserved small molecule, CAMP factor, that is co-hemolytic in the presence of Staphylococcus aureus sphingomyelinase C. While this co-hemolytic reaction is commonly used by clinical laboratories to identify GBS, the contribution of CAMP factor to GBS vaginal persistence is unknown. Using

Indexed as

AnimalsBacterial AdhesionBacterial ProteinsBacterial ToxinsBiofilmsCell LineEpithelial CellsFemaleGene DeletionHemolysin ProteinsHumansMiceMice, Inbred C57BLMucous MembranePregnancySphingomyelin PhosphodiesteraseBacterial ProteinsBacterial ToxinsCAMP protein, StreptococcusHemolysin Proteinshlb protein, Staphylococcus aureusSphingomyelin PhosphodiesterasebiofilmCAMP factorgroup B StreptococcusStaphylococcus aureusvaginal colonization

Identifiers

PMID34908468
PMCPMC8672899
OpenAlexW4200140722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.