Evidence map›Paper›PMID 34908212›Full record

ArticleHuman brain mapping2022

Distinct patterns of progressive gray and white matter degeneration in amyotrophic lateral sclerosis.

Abdullah Ishaque, Daniel Ta, Muhammad Khan, Lorne Zinman, Lawrence Korngut, Angela Genge, Annie Dionne, Hannah Briemberg, Collin Luk, Yee-Hong Yang and 8 more

Open access · goldAbstract read
In one paragraph

Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Potential Roles of Neuroimaging in Motor Neuron Disease.Current neurology and neuroscience reports · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Alteration of interoceptive sensitivity: expanding the spectrum of behavioural disorders in amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 2 countries.

Abdullah IshaqueFaculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.ORCID 0000-0001-7938-9490
Daniel TaFaculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.ORCID 0000-0002-4975-2970
Muhammad KhanNeuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada.
Lorne ZinmanDivision of Neurology, Department of Medicine, University of Toronto, Toronto, Canada.
Lawrence KorngutDepartment of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Angela GengeDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Canada.
Annie DionneDépartement des Sciences Neurologiques, Hôpital de l'Enfant-Jésus, CHU de Québec, Quebec City, Canada.
Hannah BriembergDivision of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada.
Collin LukDivision of Neurology, Department of Medicine, University of Alberta, Edmonton, Canada.
Yee-Hong YangDepartment of Computing Science, University of Alberta, Edmonton.
Christian BeaulieuDepartment of Biomedical Engineering, University of Alberta, Edmonton, Canada.
Derek EmeryDepartment of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, Canada.
Dean T EurichSchool of Public Health, University of Alberta, Edmonton, Canada.
Richard FrayneDepartment of Radiology, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
Simon GrahamDepartment of Medical Biophysics, University of Toronto, Toronto, Canada.
Alan WilmanDepartment of Biomedical Engineering, University of Alberta, Edmonton, Canada.
Nicolas DupréNeuroscience Axis, CHU de Québec, Université Laval, Quebec City, Canada.
Sanjay KalraFaculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.ORCID 0000-0003-4762-8746
University of Alberta · CADana (United States) · USUniversity of Toronto · CAAlberta Health Services · CAAllen Institute for Brain Science · USHôpital de l'Enfant-Jésus · CAMontreal Neurological Institute and Hospital · CAUniversité Laval · CAUniversity of British Columbia · CA

Funding

CIHR
6 · The paper itself

Abstract

Progressive cerebral degeneration in amyotrophic lateral sclerosis (ALS) remains poorly understood. Here, three-dimensional (3D) texture analysis was used to study longitudinal gray and white matter cerebral degeneration in ALS from routine T1-weighted magnetic resonance imaging (MRI). Participants were included from the Canadian ALS Neuroimaging Consortium (CALSNIC) who underwent up to three clinical assessments and MRI at four-month intervals, up to 8 months after baseline (T

Indexed as

Amyotrophic Lateral SclerosisWhite MatterBrainCanadaHumansMagnetic Resonance Imaging

Identifiers

PMID34908212
PMCPMC8886653
OpenAlexW4200485149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.