ArticleProtein engineering, design & selection : PEDS2021
DE-STRESS: a user-friendly web application for the evaluation of protein designs.
Article in Protein engineering, design & selection : PEDS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The Protein Design Archive (PDA): insights from 40 years of protein design.Nature biotechnology · 2025Article
- Tuning ProteinMPNN to reduce protein visibility via MHC Class I through direct preference optimization.Protein engineering, design & selection : PEDS · 2025Article
- A novel decoding strategy for ProteinMPNN to design with less visibility to cytotoxic T-lymphocytes.Computational and structural biotechnology journal · 2025Article
- Aggrescan4D: A comprehensive tool for pH-dependent analysis and engineering of protein aggregation propensity.Protein science : a publication of the Protein Society · 2024Review
- PDBench: evaluating computational methods for protein-sequence design.Bioinformatics (Oxford, England) · 2023Article
- Guiding protein design choices by per-residue energy breakdown analysis with an interactive web application.Frontiers in molecular biosciences · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
De novo protein design is a rapidly growing field, and there are now many interesting and useful examples of designed proteins in the literature. However, most designs could be classed as failures when characterised in the lab, usually as a result of low expression, misfolding, aggregation or lack of function. This high attrition rate makes protein design unreliable and costly. It is possible that some of these failures could be caught earlier in the design process if it were quick and easy to generate information and a set of high-quality metrics regarding designs, which could be used to make reproducible and data-driven decisions about which designs to characterise experimentally. We present DE-STRESS (DEsigned STRucture Evaluation ServiceS), a web application for evaluating structural models of designed and engineered proteins. DE-STRESS has been designed to be simple, intuitive to use and responsive. It provides a wealth of information regarding designs, as well as tools to help contextualise the results and formally describe the properties that a design requires to be fit for purpose.
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Registered trials
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