Evidence map›Paper›PMID 34907761›Full record

ReviewJournal of applied biomedicine2021

Does the enriched environment alter memory capacity in malnourished rats by modulating BDNF expression?

Waleska Maria Almeida Barros, Matheus Santos de Sousa Fernandes, Roberta Karlize Pereira Silva, Karollainy Gomes da Silva, Ana Patricia da Silva Souza, Mariluce Rodrigues Marques Silva, Ana Beatriz Januario da Silva, Gabriela Carvalho Jurema Santos, Maria Eduarda Rodrigues Alves Dos Santos, Taciane Silva do Carmo and 2 more

Open access · goldAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of applied biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Waleska Maria Almeida BarrosUniversidade Federal de Pernambuco, Programa de Pos-graduacao em Neuropsiquiatria e Ciencias do Comportamento, Recife, Brasil.
Matheus Santos de Sousa FernandesUniversidade Federal de Pernambuco, Programa de Pos-graduacao em Neuropsiquiatria e Ciencias do Comportamento, Recife, Brasil.
Roberta Karlize Pereira SilvaCentro Universitario Facol / Centro Integrado de Tecnologias em Neurociencia (CITENC), Vitoria de Santo Antao, Brasil.
Karollainy Gomes da SilvaCentro Universitario Facol / Centro Integrado de Tecnologias em Neurociencia (CITENC), Vitoria de Santo Antao, Brasil.
Ana Patricia da Silva SouzaUniversidade Federal de Pernambuco, Programa de Pos-graduacao em Neuropsiquiatria e Ciencias do Comportamento, Recife, Brasil.
Mariluce Rodrigues Marques SilvaUniversidade Federal de Pernambuco, Programa de Pos-graduacao em Neuropsiquiatria e Ciencias do Comportamento, Recife, Brasil.
Ana Beatriz Januario da SilvaUniversidade Federal de Pernambuco, Programa de Pos-graduacao em Neuropsiquiatria e Ciencias do Comportamento, Recife, Brasil.
Gabriela Carvalho Jurema SantosUniversidade Federal de Pernambuco, Programa de Pos-Graduacao em Nutricao, Recife, Brasil.
Maria Eduarda Rodrigues Alves Dos SantosCentro Universitario Facol / Centro Integrado de Tecnologias em Neurociencia (CITENC), Vitoria de Santo Antao, Brasil.
Taciane Silva do CarmoCentro Universitario Facol / Centro Integrado de Tecnologias em Neurociencia (CITENC), Vitoria de Santo Antao, Brasil.
Sandra Lopes de SouzaUniversidade Federal de Pernambuco, Programa de Pos-graduacao em Neuropsiquiatria e Ciencias do Comportamento, Recife, Brasil.
Viviane de Oliveira Nogueira SouzaUniversidade Federal de Pernambuco, Centro Academico Vitoria, Nucleo de Nutricao, Vitoria de Santo Antao, Brasil.
Universidade Federal de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Environmental factors interfere in the neural plasticity processes. Among these, malnutrition in the early stages of life stands out as one of the main non-genetic factors that can interfere in the morphofunctional development of the nervous system. Furthermore, sensory stimulation from enriched environments (EE) also interferes with neural development. These two factors can modify areas related to memory and learning as the hippocampus, through mechanisms related to the gene expression of brain-derived neurotrophic factor (BDNF). The BDNF may interfere in synaptic plasticity processes, such as memory. In addition, these changes in early life may affect the functioning of the hippocampus during adulthood through mechanisms mediated by BDNF. Therefore, this study aims to conduct a literature review on the effects of early malnutrition on memory and the relationship between the underlying mechanisms of EE, BDNF gene expression, and memory. In addition, there are studies that demonstrate the effect of EE reversal on exposure to changes in the functioning of hippocampal malnutrition in adult rats that were prematurely malnourished. Thereby, evidence from the scientific literature suggests that the mechanisms of synaptic plasticity in the hippocampus of adult animals are influenced by malnutrition and EE, and these alterations may involve the participation of BDNF as a key regulator in memory processes in the adult animal hippocampus.

Indexed as

Brain-Derived Neurotrophic FactorMalnutritionMemoryAnimalsEnvironmentHippocampusNeuronal PlasticityRatsBrain-Derived Neurotrophic FactorBDNFEnriched environmentHippocampal formationMalnutritionMemory, Neural plasticity

Identifiers

PMID34907761
OpenAlexW3198335967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.