Evidence map›Paper›PMID 34907737›Full record

ArticleJournal of applied biomedicine2021

Does GD2 synthase (GD2S) detect cancer stem cells in blood samples of breast carcinomas?

Maryam Mansoori, Isa Abdi Rad, Alireza Mirzaei, Kevin J Tam, Seyed Mohsen Hosseini, Rahim Mahmodlu, Fatemeh Mansouri, Leili Saeednejad Zanjani, Zahra Madjd

Open access · goldAbstract read
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In one paragraph

Article in Journal of applied biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Maryam MansooriIran University of Medical Sciences, Oncopathology Research Center, Tehran, Iran.
Isa Abdi RadUrmia University of Medical Sciences, Cellular and Molecular Research Center, Urmia, Iran.
Alireza MirzaeiIran University of Medical Sciences, Shafa Orthopedic Hospital, Bone and Joint Reconstruction Research Center, Tehran, Iran.
Kevin J TamUniversity of British Columbia, Vancouver Prostate Centre, Department of Urologic Sciences, Vancouver, Canada.
Seyed Mohsen HosseiniOmid specialty and subspecialty Hospital, Oncology and Radiotherapy Ward, Urmia, Iran.
Rahim MahmodluUrmia University of Medical Sciences, Faculty of Medicine, Imam Khomeini Hospital, Department of Surgery, Urmia, Iran.
Fatemeh MansouriUrmia University of Medical Sciences, Faculty of Medicine, Department of Genetics and Immunology, Urmia, Iran.
Leili Saeednejad ZanjaniIran University of Medical Sciences, Oncopathology Research Center, Tehran, Iran.
Zahra MadjdIran University of Medical Sciences, Oncopathology Research Center, Tehran, Iran.
Iran University of Medical Sciences · IRUrmia University · IRUniversity of British Columbia · CAUrmia University of Medical Sciences

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCancer stem cells (CSCs) are a theorized subset of cells within the tumor that is thought to drive disease recurrence and metastatic spread. The aim of this study is to investigate mRNA and protein levels of ganglioside GD2 synthase (GD2S), in breast cancer (BC) patients.

methods65 PBMCs of preoperative BC patients without chemotherapy were compared to PBMCs after chemotherapy and controls.

resultsGD2S were significantly higher in BC patients after chemotherapy compared to pre-chemotherapy at both mRNA and protein. GD2S was higher in pre-chemotherapy blood samples compared to control samples.

conclusionsHigher expression of GD2S in BC samples compared to healthy control indicates the potential utility of GD2S as a marker of malignancy.

Indexed as

Breast NeoplasmsN-AcetylgalactosaminyltransferasesNeoplasm Recurrence, LocalNeoplastic Stem CellsFemaleHumansRNA, MessengerN-Acetylgalactosaminyltransferases(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferaseRNA, MessengerBreast cancerCancer stem cellCirculating cancer stem cellELISAqRT-PCR

Identifiers

PMID34907737
OpenAlexW3201635595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.