Evidence map›Paper›PMID 34907727›Full record

ArticleJournal of applied biomedicine2020

Association of FGF19, FGF21 and FGF23 with carbohydrate metabolism parameters and insulin resistance in patients with chronic kidney disease.

Malgorzata Marchelek-Mysliwiec, Violetta Dziedziejko, Katarzyna Dolegowka, Andrzej Pawlik, Krzysztof Safranow, Joanna Stepniewska, Magda Wisniewska, Jolanta Malyszko, Kazimierz Ciechanowski

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Article in Journal of applied biomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Malgorzata Marchelek-MysliwiecPomeranian Medical University, Clinical Department of Nephrology, Transplantology and Internal Medicine, Szczecin, Poland.
Violetta DziedziejkoPomeranian Medical University, Department of Biochemistry and Medical Chemistry, Szczecin, Poland.
Katarzyna DolegowkaPomeranian Medical University, Clinical Department of Nephrology, Transplantology and Internal Medicine, Szczecin, Poland.
Andrzej PawlikPomeranian Medical University, Department of Physiology, Szczecin, Poland.
Krzysztof SafranowPomeranian Medical University, Department of Biochemistry and Medical Chemistry, Szczecin, Poland.
Joanna StepniewskaPomeranian Medical University, Clinical Department of Nephrology, Transplantology and Internal Medicine, Szczecin, Poland.
Magda WisniewskaPomeranian Medical University, Clinical Department of Nephrology, Transplantology and Internal Medicine, Szczecin, Poland.
Jolanta MalyszkoWarsaw Medical University, Department of Nephrology, Dialysis and Internal Medicine, Warsaw, Poland.
Kazimierz CiechanowskiPomeranian Medical University, Clinical Department of Nephrology, Transplantology and Internal Medicine, Szczecin, Poland.
Pomeranian Medical University · PLMedical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin resistance (IR) is characterised by increased gluconeogenesis in the liver and the resistance of peripheral receptors to insulin. Several factors, including IR, type 2 diabetes, new-onset diabetes after transplant (NODAT) and secondary parathyroidism, are related to chronic kidney disease (CKD). These factors are associated with higher mortality due to the increased risk of cardiovascular complications. Many factors have been identified as potential markers of IR in CKD. These factors include fibroblast growth factors (FGFs), a subfamily of endocrine polypeptides. In this study, we examined the association of FGF19, FGF21 and FGF23 with selected parameters related to carbohydrate metabolism and insulin resistance in non diabetic patients with predialysis CKD and in non diabetic patients after renal transplantation. The study included 108 non diabetic subjects: 40 patients with predialysis CKD, 45 patients with CKD who had undergone renal transplantation, and 23 healthy subjects (control group). In patients who had undergone renal transplantation, concentrations of FGF23 were increased compared to the control group and patients with predialysis CKD. The highest and lowest FGF19 concentrations were observed in CKD patients and in patients who had undergone kidney transplantation, respectively. This difference was statistically significant. Leptin concentrations were higher in CKD patients compared to the control group and patients who had undergone kidney transplantation. There were no statistically significant differences in adiponectin concentrations, lean body mass or fat tissue mass between the studied groups. HOMA-IR and insulin levels were significantly increased in CKD patients and in patients who had undergone renal transplantation in comparison to the control group. The results of the study suggest the involvement of FGF in carbohydrate metabolism and insulin resistance in patients with predialysis CKD, as well as a correlation with kidney function.

Indexed as

Carbohydrate MetabolismFibroblast Growth FactorsInsulin ResistanceRenal Insufficiency, ChronicDiabetes Mellitus, Type 2FemaleFibroblast Growth Factor-23HumansInsulinMaleFGF19 protein, humanFGF23 protein, humanfibroblast growth factor 21Fibroblast Growth Factor-23Fibroblast Growth FactorsInsulinBody compositionChronic kidney diseaseFGF19FGF21FGF23Insulin

Identifiers

PMID34907727
OpenAlexW3009015675

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.