Evidence map›Paper›PMID 34907697›Full record

ArticleJournal of applied biomedicine2019

Reshaping cortical activity with subthalamic stimulation in Parkinson's disease during finger tapping and gait mapped by near infrared spectroscopy.

Ondrej Klempir, Radim Krupicka, Jan Mehnert, Vaclav Cejka, Kamila Polakova, Hana Brozova, Zoltan Szabo, Evzen Ruzicka, Robert Jech

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Article in Journal of applied biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ondrej KlempirCzech Technical University in Prague, Faculty of Biomedical Engineering, Department of Biomedical Informatics, Kladno, Czech Republic.
Radim KrupickaCzech Technical University in Prague, Faculty of Biomedical Engineering, Department of Biomedical Informatics, Kladno, Czech Republic.
Jan MehnertUniversity Medical Center Eppendorf, Department of Systems Neuroscience, Hamburg, Germany.
Vaclav CejkaCzech Technical University in Prague, Faculty of Biomedical Engineering, Department of Biomedical Informatics, Kladno, Czech Republic.
Kamila PolakovaCharles University, First Faculty of Medicine and General University Hospital, Department of Neurology, Prague, Czech Republic.
Hana BrozovaCharles University, First Faculty of Medicine and General University Hospital, Department of Neurology, Prague, Czech Republic.
Zoltan SzaboCzech Technical University in Prague, Faculty of Biomedical Engineering, Department of Biomedical Informatics, Kladno, Czech Republic.
Evzen RuzickaCharles University, First Faculty of Medicine and General University Hospital, Department of Neurology, Prague, Czech Republic.
Robert JechCharles University, First Faculty of Medicine and General University Hospital, Department of Neurology, Prague, Czech Republic.

Funding

Czech Ministry of Health 16-28119aCzech Ministry of Health 17-32318aCzech Science foundation GACR 16-13323S
6 · The paper itself

Abstract

Exploration of motor cortex activity is essential to understanding the pathophysiology in Parkinson's Disease (PD), but only simple motor tasks can be investigated using a fMRI or PET. We aim to investigate the cortical activity of PD patients during a complex motor task (gait) to verify the impact of deep brain stimulation in the subthalamic nucleus (DBS-STN) by using Near-Infrared-Spectroscopy (NIRS). NIRS is a neuroimaging method of brain cortical activity using low-energy optical radiation to detect local changes in (de)oxyhemoglobin concentration. We used a multichannel portable NIRS during finger tapping (FT) and gait. To determine the signal activity, our methodology consisted of a pre-processing phase for the raw signal, followed by statistical analysis based on a general linear model. Processed recordings from 9 patients were statistically compared between the on and off states of DBS-STN. DBS-STN led to an increased activity in the contralateral motor cortex areas during FT. During gait, we observed a concentration of activity towards the cortex central area in the "stimulation-on" state. Our study shows how NIRS can be used to detect functional changes in the cortex of patients with PD with DBS-STN and indicates its future use for applications unsuited for PET and a fMRI.

Indexed as

Deep brain stimulationGaitNear infrared spectroscopyNeuroinformaticsParkinson's diseaseSubthalamic nucleus

Identifiers

PMID34907697

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.