SynthesisUnited European gastroenterology journal2022
Composite outcomes in observational studies of ulcerative colitis: A systematic review and meta-analysis.
Synthesis in United European gastroenterology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Composite outcomes in observational studies of ulcerative colitis: A systematic review and meta-analysis.United European gastroenterology journal · 2022Pooled it
- Defining Disabling Disease in Moderate-to-Severe Ulcerative Colitis: Beyond Treatment Escalation.Journal of gastroenterology and hepatology · 2026Article
- Methodological Considerations in Defining Disabling Disease Trajectories in Moderate-to-Severe Ulcerative Colitis.Journal of gastroenterology and hepatology · 2026Article
- Beyond Colectomy-Interpreting Long-Term Disease Burden and Clinical Trajectories in Moderate-to-Severe Ulcerative Colitis.Journal of gastroenterology and hepatology · 2026Article
- Five-Year Outcomes and Disease Trajectories in Moderate-to-Severe Ulcerative Colitis: A Korean Multicenter Inception Cohort.Journal of gastroenterology and hepatology · 2026Article
- How many biomarker measurements are needed to predict prognosis in Crohn's disease patients under infliximab?-A prospective study.United European gastroenterology journal · 2023Observational
- Mild to moderate ulcerative colitis: Call me by my name.United European gastroenterology journal · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUlcerative colitis (UC) has been the focus of numerous observational studies over the years and a common strategy employed in their design is the use of composite and aggregate outcomes.
objectiveThis systematic review and meta-analysis aims to identify composite and aggregate outcomes of observational studies in UC and to evaluate how the number and type of variables included and the length of follow-up affect the frequency of patients that achieve these outcomes.
methodsA systematic literature search was carried out using MEDLINE [via PubMed], Scopus, and Web of Science online databases. Observational studies that included UC patients and reported composite or aggregate outcomes were identified. A set of variables considered to be representative of progressive or disabling UC was defined, the proportion of patients attaining the outcomes was determined and a random-effects meta-analysis was performed by dividing the identified studies into subgroups according to different criteria of interest.
resultsA total of 10,264 records were identified in the systematic search, of which 33 were retained for qualitative analysis and 20 were included in the meta-analysis. The mean frequency for composite outcomes was 0.363 [95% confidence interval (CI) 0.323-0.403]. The frequency of composite outcome for the subgroup of studies that included the variable "Biologics" was significantly higher than for those in which this variable was not reported [0.410; 95% CI 0.364-0.457 versus 0.298; 95% CI 0.232-0.364; p = 0.006]. Composite outcomes were also more frequent as the follow-up duration increased.
conclusionThe frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported. Moreover, longer follow-up periods are associated with higher frequencies of composite outcomes. The evidence provided here is useful for the design of future observational studies of UC that aim to maximize the frequency of patients that achieve composite outcomes.
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