Evidence map›Paper›PMID 34907594›Full record

Trial reportJournal of gastroenterology and hepatology2022

Effect of remimazolam tosilate on early cognitive function in elderly patients undergoing upper gastrointestinal endoscopy.

Yingjie Tan, Wen Ouyang, Yongzhong Tang, Ning Fang, Chao Fang, Chengxuan Quan

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of gastroenterology and hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05980117 (Comparison of Remimazolam vs. Midazolam for Sedation During Cataract Surgery), which is not on this map. Cited by 59 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 8 pooled it
24.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05980117 phase4recruitingnot on this mapstarted 2025, after this paper: background citation

Comparison of Remimazolam vs. Midazolam for Sedation During Cataract Surgery

TypeinterventionalSponsorUniversity of California, Los AngelesRan2025 to 2026Enrolled120ConditionsCataract Surgery, Cognitive ImpairmentArmsRemimazolam, Midazolam
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 8 syntheses or guidelines pooled it, 123 citations in OpenAlex.

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  8. RemimazolamPeerJ · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yingjie TanDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, China.ORCID https://orcid.org/0000-0003-3349-4345
Wen OuyangDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Yongzhong TangDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Ning FangDepartment of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
Chao FangNational Drug Clinical Trail Center, Hunan Cancer Hospital, Changsha, China.
Chengxuan QuanDepartment of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNHunan Cancer Hospital · CN

Funding

Hunan Health and Family Planning Commission 20201802Medical Research Fund of Hunan Medical Association HMA202101003States' Key Project of Research and Development Plan 2018yfc2001800
6 · The paper itself

Abstract

BACKGROUND AND

aimRemimazolam tosilate (RT) is under evaluation as a sedative for endoscopic procedures. Herein, we aimed to evaluate safety including cognition recovery of RT administered in elderly patients undergoing upper gastrointestinal endoscopy and assess its safety dosage.

methodsNinety-nine patients presenting for upper gastrointestinal endoscopy were randomized to receive 0.1 mg/kg RT (R1) or 0.2 mg/kg RT (R2), or propofol (P). Cognitive functions (memory, attention, and executive function) were measured via neuropsychological tests conducted before sedation and 5 min after recovery to full alertness. Adverse events were also assessed.

resultsThere were no statistical differences between postoperative and baseline results for R1 group and P group, whereas those for R2 group revealed worsened postoperative cognitive functions (immediate recall and short delay recall) than baseline (P < 0.05). Compared with P group, Scores demonstrated worse restoration of immediate recall in R1 group, immediate recall, short-delayed recall, and attention function in R2 group (P < 0.05). Patients in R2 group had a longer sedation time (12.09 vs 8.27 vs 8.21 min; P < 0.001) and recovery time (6.85 vs 3.82 vs 4.33 min; P < 0.001) than that in R1 group and P group. Moreover, the incidence of hypotension was 3.0% in R1 group, whereas it was 21.2% in R2 group and 48.5% in P group (P < 0.05).

conclusionThe addition of 0.1 mg/kg RT as an adjunct to opiate sedation for upper gastrointestinal endoscopy not only achieves more stable perioperative hemodynamics but also achieves acceptable neuropsychiatric functions in elderly patients.

Indexed as

BenzodiazepinesCognitionEndoscopy, GastrointestinalAgedHumansHypnotics and SedativesNeuropsychological TestsPropofolBenzodiazepinesHypnotics and SedativesPropofolremimazolamCognitive functionElderly patientsEndoscopic sedationRemimazolam tosilateUpper gastrointestinal endoscopy

Identifiers

PMID34907594
PMCPMC9303590
OpenAlexW4200303933

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.