ArticleAnalytical and bioanalytical chemistry2022
Development and validation of an LC-MS/MS method for the quantitation of 30 legacy and emerging per- and polyfluoroalkyl substances (PFASs) in human plasma, including HFPO-DA, DONA, and cC6O4.
Article in Analytical and bioanalytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses.Environmental health : a global access science source · 2023Pooled it
- Multi-class UHPLC-MS/MS method for the simultaneous determination of 32 endocrine-disrupting chemicals in the urine of pregnant women.Analytical and bioanalytical chemistry · 2026Article
- Analysis and fate of per- and polyfluoroalkyl substances (PFAS) in the global aquatic environment: perspectives and combined risks with microplastics.Analytical and bioanalytical chemistry · 2026Review
- Evaluation of isotope-dilution mass spectrometry, internal standard, and external standard methods for PFAS quantification in tap water and soil.Analytical and bioanalytical chemistry · 2026Article
- Establishment and application of a QuEChERS-based high-performance liquid chromatography-mass spectrometry method for the analysis of 56 per- and polyfluoroalkyl substances in human plasma.Analytical and bioanalytical chemistry · 2026Article
- [Development of a machine learning-based ionization efficiency prediction model for per- and polyfluoroalkyl substances and its application in semi-quantitative analysis].Se pu = Chinese journal of chromatography · 2026Article
- Exposure to PFOA and GenX elicits cell typespecific impacts on p53 and TGF-β signaling pathways.Molecular biology reports · 2026Article
- An overview of the impact of PFAS on animals, humans, and the environment using a One Health approach.Environmental science and pollution research international · 2026Review
- Multiple linear regression modeling with values below a lower limit of quantification - a statistical method comparison.BMC medical research methodology · 2026Article
- Multiple contaminant detection in commercially available chicken-based cat kibbles in Italy.Frontiers in veterinary science · 2026Article
- Novel LC-MS/MS Method for Monitoring Perfluoroalkyl and Polyfluoroalkyl Substances in Companion Animal Blood Plasma and Serum: Environmental and Health Implications.International journal of veterinary science and medicine · 2026Article
- Quality assurance and quality control for human biomonitoring data-focus on matrix reference materials.Analytical and bioanalytical chemistry · 2025Review
- Perfluoroalkyl substances and preterm birth.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Health Impacts of Per- and Polyfluoroalkyl Substances (PFASs): A Comprehensive Review.Life (Basel, Switzerland) · 2025Review
- Latest trends in the environmental analysis of PFAS including nontarget analysis and EOF-, AOF-, and TOP-based methodologies.Analytical and bioanalytical chemistry · 2025Review
- Unveiling the Research Void: Exploring the Reproductive Effects of PFAS Compounds on Male Health.Advances in experimental medicine and biology · 2025Review
- The Critical Role of Commercial Analytical Reference Standards in the Control of Chemical Risks: The Case of PFAS and Ways Forward.Environmental health perspectives · 2025Article
- Monitoring of per- and polyfluoroalkyl substances (PFAS) in human blood samples collected in three regions with known PFAS releases in the environment and three control regions in South Germany.Archives of toxicology · 2024Article
- PFAS and their association with the increased risk of cardiovascular disease in postmenopausal women.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- The EU's Per- and Polyfluoroalkyl Substances (PFAS) Ban: A Case of Policy over Science.Toxics · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Per- and polyfluoroalkyl substances (PFASs) include persistent organic pollutants whose spread is still ubiquitous. Efforts to substitute substances of high concern with fluorinated alternatives, such as HFPO-DA (GenX), DONA (ADONA), and cC6O4, have been made. The aim of this work was to develop and validate an isotopic dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) method suitable to quantify 30 PFASs in human plasma. Analytes included legacy PFASs (PFOA, PFOS, and PFHxS), fluorinated alternatives (PFBA, PFBS, 6:2 FTSA, HFPO-DA, DONA, and cC6O4), and newly identified compounds (F-53B and PFECHS). The sample preparation was rapid and consisted of simple protein precipitation and centrifugation. Calibration standards and quality control solutions were prepared with a human pooled plasma containing relatively low background levels of the considered analytes. A complete validation was carried out: the lower limits of quantitation (LLOQs) ranged from 0.009 to 0.245 µg/L; suitable linearity (determination coefficients, R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.