Evidence map›Paper›PMID 34907252›Full record

ArticleScientific reports2021

Modulation of oxidative and nitrosative stress attenuates microvascular hyperpermeability in ovine model of Pseudomonas aeruginosa sepsis.

Satoshi Fukuda, Yosuke Niimi, Yasutaka Hirasawa, Ennert R Manyeza, C Edwin Garner, Garry Southan, Andrew L Salzman, Donald S Prough, Perenlei Enkhbaatar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Subcellular Localization Guides eNOS Function.International journal of molecular sciences · 2024
    Review
  5. Neonatal sepsis and Kawasaki disease.European journal of pediatrics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Satoshi FukudaDepartment of Anesthesiology, Medical Branch, University of Texas, 301 University Boulevard, Galveston, TX, 77555, USA.
Yosuke NiimiDepartment of Anesthesiology, Medical Branch, University of Texas, 301 University Boulevard, Galveston, TX, 77555, USA.
Yasutaka HirasawaDepartment of Anesthesiology, Medical Branch, University of Texas, 301 University Boulevard, Galveston, TX, 77555, USA.
Ennert R ManyezaDepartment of Anesthesiology, Medical Branch, University of Texas, 301 University Boulevard, Galveston, TX, 77555, USA.
C Edwin GarnerSalzman Group Inc., Beverly, MA, 01915, USA.
Garry SouthanSalzman Group Inc., Beverly, MA, 01915, USA.
Andrew L SalzmanSalzman Group Inc., Beverly, MA, 01915, USA.
Donald S ProughDepartment of Anesthesiology, Medical Branch, University of Texas, 301 University Boulevard, Galveston, TX, 77555, USA.
Perenlei EnkhbaatarDepartment of Anesthesiology, Medical Branch, University of Texas, 301 University Boulevard, Galveston, TX, 77555, USA. peenkhba@utmb.edu.
The University of Texas Medical Branch at Galveston · USChiba University · JP

Funding

Etiology of Microvascular Changes in Gram-positive Sepsis: Mechanisms and Therapeutic OptionsR01GM097480 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ENKHBAATAR, PERENLEI · 2012 to 2022
$2.7M
NIGMS NIH HHS R01 GM097480
6 · The paper itself

Abstract

In sepsis, microvascular hyperpermeability caused by oxidative/nitrosative stress (O&NS) plays an important role in tissue edema leading to multi-organ dysfunctions and increased mortality. We hypothesized that a novel compound R-107, a modulator of O&NS, effectively ameliorates the severity of microvascular hyperpermeability and preserves multi-organ function in ovine sepsis model. Sepsis was induced in twenty-two adult female Merino sheep by intravenous infusion of Pseudomonas aeruginosa (PA) (1 × 10

Indexed as

Pseudomonas InfectionsSepsisAnimalsCapillary PermeabilityDisease Models, AnimalFemaleFree Radical ScavengersNitrosative StressPseudomonas aeruginosaSheepFree Radical Scavengers

Identifiers

PMID34907252
PMCPMC8671546
OpenAlexW4225487085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.