Evidence map›Paper›PMID 34907205›Full record

ArticleNature communications2021

Nanoparticles and photochemistry for native-like transmembrane protein footprinting.

Jie Sun, Xiaoran Roger Liu, Shuang Li, Peng He, Weikai Li, Michael L Gross

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Precursor Reagent Hydrophobicity Affects Membrane Protein Footprinting.Journal of the American Society for Mass Spectrometry · 2023
    Article
  10. Article
  11. Article
  12. Review
  13. Article
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  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jie SunDepartment of Chemistry, Washington University in St. Louis, One Brookings Drive, Box 1134, Saint Louis, MO, 63130, USA.ORCID http://orcid.org/0000-0001-8775-5032
Xiaoran Roger LiuDepartment of Chemistry, Washington University in St. Louis, One Brookings Drive, Box 1134, Saint Louis, MO, 63130, USA.ORCID http://orcid.org/0000-0003-3198-1588
Shuang LiDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Ave, Box 8231, St. Louis, MO, 63110, USA.
Peng HeDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Ave, Box 8231, St. Louis, MO, 63110, USA.
Weikai LiDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Ave, Box 8231, St. Louis, MO, 63110, USA. weikai@wustl.edu.
Michael L GrossDepartment of Chemistry, Washington University in St. Louis, One Brookings Drive, Box 1134, Saint Louis, MO, 63130, USA. mgross@wustl.edu.ORCID http://orcid.org/0000-0003-1159-4636
Washington University in St. Louis · US

Funding

TrainingP41GM103422 · NIGMS · WASHINGTON UNIVERSITY · PI YARASHESKI, KEVIN E · 2012 to 2019
$12.0M
STRUCTURAL AND FUNCTIONAL BASIS OF THE VITAMIN K CYCLER01HL121718 · NHLBI · WASHINGTON UNIVERSITY · PI Weikai Li · 2014 to 2026
$5.2M
NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID MEMBRANES AND CELLSR01GM131008 · NIGMS · WASHINGTON UNIVERSITY · PI MICHAEL L GROSS, Weikai Li · 2019 to 2026
$3.8M
A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical ProjectsR24GM136766 · NIGMS · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2020 to 2022
$2.3M
NHLBI NIH HHS R01 HL121718NIGMS NIH HHS P41 GM103422NIGMS NIH HHS R01 GM131008NIGMS NIH HHS R24 GM136766
6 · The paper itself

Abstract

Mass spectrometry-based footprinting can probe higher order structure of soluble proteins in their native states and serve as a complement to high-resolution approaches. Traditional footprinting approaches, however, are hampered for integral membrane proteins because their transmembrane regions are not accessible to solvent, and they contain hydrophobic residues that are generally unreactive with most chemical reagents. To address this limitation, we bond photocatalytic titanium dioxide (TiO

Indexed as

Binding SitesLigandsLipid BilayersLiposomesMass SpectrometryMembrane ProteinsNanoparticlesPhotochemical ProcessesProtein ConformationProtein FootprintingReactive Oxygen SpeciesTitaniumLigandsLipid BilayersLiposomesMembrane ProteinsReactive Oxygen SpeciesTitaniumtitanium dioxide

Identifiers

PMID34907205
PMCPMC8671412
OpenAlexW4200206654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.