Evidence map›Paper›PMID 34907068›Full record

ArticleBMJ open2021

PR interval prolongation and 1-year mortality among emergency department patients: a multicentre transnational cohort study.

Rune Vad, Tobias Malte Larsen, Helene Kildegaard, Mikkel Brabrand, Jakob Lundager Forberg, Ulf Ekelund, Anton Pottegard, Annmarie Touborg Lassen

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Value of frontal QRS axis for risk stratification of individuals with prolonged PR interval.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Rune VadDepartment of Emergency Medicine, Odense University Hospital, Odense, Syddanmark, Denmark rune@vadpedersen.dk.ORCID 0000-0001-8551-856X
Tobias Malte LarsenDepartment of Emergency Medicine, Odense University Hospital, Odense, Syddanmark, Denmark.
Helene KildegaardClinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark.
Mikkel BrabrandDepartment of Emergency Medicine, Southwest Jutland Hospital Esbjerg, Esbjerg, Denmark.
Jakob Lundager ForbergDepartment of Emergency Medicine and Prehospital Care, Helsingborgs lasarett, Helsingborg, Sweden.
Ulf EkelundDepartment of Emergency Medicine, Lunds Universitet, Lund, Sweden.
Anton PottegardClinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Syddanmark, Denmark.
Annmarie Touborg LassenDepartment of Emergency Medicine, Odense University Hospital, Odense, Syddanmark, Denmark.ORCID 0000-0003-4942-6152
Odense University Hospital · DKUniversity of Southern Denmark · DKHelsingborgs lasarett · SEHospital South West Jutland · DKLund University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEmerging evidence supports that PR interval prolongation is associated with increased mortality. However, most previous studies have limited confounder control, and clinical impact in a population of acute ill patients is unknown. The aim of this study was to investigate whether 1-year all-cause mortality was increased in patients presenting with PR interval prolongation in the emergency department (ED). DESIGN AND

settingWe conducted a register-based cohort study in two Swedish and two Danish EDs. We included all adult patients with an ECG performed at arrival to the Danish EDs during March 2013 to May 2014 and Swedish EDs during January 2010 to January 2011. Using propensity score matching, we analysed HR for 1-year all-cause mortality comparing patients with PR interval prolongation (>200 ms) and normal PR interval (120-200 ms). PARTICIPANTS AND

resultsWe included 106 124 patients. PR interval prolongation occurred in 8.9% (95% CI 8.7% to 9.0%); these patients were older and had more comorbidity than those with a normal PR interval. The absolute 1-year risk of death was 13% (95% CI 12.3% to 13.7%) for patients with PR interval prolongation and 7.9% (95% CI 7.7% to 8.0%) for those without. After confounder adjustments by propensity score matching, PR interval prolongation showed no association with 1-year mortality with a HR of 1.00 (95% CI 0.93% to 1.08%).

conclusionPR interval prolongation does not constitute an independent risk factor for 1-year mortality in ED patients.

Indexed as

Atrioventricular BlockElectrocardiographyAdultCohort StudiesEmergency Service, HospitalHumansRisk Factorsaccident & emergency medicinecardiac epidemiologyepidemiology

Identifiers

PMID34907068
PMCPMC8672022
OpenAlexW4200459060

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.