Evidence map›Paper›PMID 34907026›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Presynaptic Mitochondrial Volume and Packing Density Scale with Presynaptic Power Demand.

Karlis A Justs, Zhongmin Lu, Amit K Chouhan, Jolanta A Borycz, Zhiyuan Lu, Ian A Meinertzhagen, Gregory T Macleod

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

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  8. Frogs uncouple neural activity from oxygen consumption after hibernation.bioRxiv : the preprint server for biology · 2026
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  18. Neural Processing without OPhysiology (Bethesda, Md.) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Karlis A JustsIntegrative Biology and Neuroscience Graduate Program, Florida Atlantic University, Jupiter, Florida 33458.
Zhongmin LuIntegrative Biology and Neuroscience Graduate Program, Florida Atlantic University, Jupiter, Florida 33458.
Amit K ChouhanWellcome - MRC Institute of Metabolic Science, University of Cambridge, Cambridge CB2 0QQ, United Kingdom.
Jolanta A BoryczDepartment of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Zhiyuan LuDepartment of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Ian A MeinertzhagenDepartment of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Gregory T MacleodJupiter Life Sciences Initiative, Florida Atlantic University, Jupiter, Florida 33458 macleodg@fau.edu.ORCID 0000-0003-3782-6968
Dalhousie University · CAJupiter Medical Center · USWellcome/MRC Institute of Metabolic Science · GB

Funding

The multiple roles of mitochondria in synaptic transmissionR01NS061914 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MACLEOD, GREGORY TALISKER · 2008 to 2016
$2.6M
The impact of synaptic cleft pH fluctuations on short-term synaptic plasticityR01NS103906 · NINDS · FLORIDA ATLANTIC UNIVERSITY · PI MACLEOD, GREGORY TALISKER · 2019 to 2022
$1.3M
The impact of synaptic cleft pH fluctuations on short-term synaptic plasticityR56NS103906 · NINDS · FLORIDA ATLANTIC UNIVERSITY · PI MACLEOD, GREGORY TALISKER · 2018 to 2018
$395k
NINDS NIH HHS R01 NS061914NINDS NIH HHS R01 NS103906NINDS NIH HHS R56 NS103906
6 · The paper itself

Abstract

Stable neural function requires an energy supply that can meet the intense episodic power demands of neuronal activity. Neurons have presumably optimized the volume of their bioenergetic machinery to ensure these power demands are met, but the relationship between presynaptic power demands and the volume available to the bioenergetic machinery has never been quantified. Here, we estimated the power demands of six motor nerve terminals in female

Indexed as

AnimalsBrainDrosophilaEnergy MetabolismFemaleMitochondriaMitochondrial SizeMotor NeuronsPresynaptic TerminalsSynaptic Transmissioncalciumelectron microscopyenergymitochondriaoxidativepresynaptic

Identifiers

PMID34907026
PMCPMC8824500
OpenAlexW4200060200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.