ArticleNeurology2022
Association of Cognitive Impairment With Free Water in the Nucleus Basalis of Meynert and Locus Coeruleus to Transentorhinal Cortex Tract.
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Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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28citing papers in PubMed, 1 pooled it
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Cognitive and brain morphological deviations in middle-to-old aged autistic adults: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Lithium Aspartate for Long COVID Fatigue and Cognitive Dysfunction: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Daily heart rate variability biofeedback training decreases locus coeruleus MRI contrast in younger adults in a randomized clinical trial.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Trial
- Diffusion MRI and α-Synuclein Seed Amplification Status in Parkinson's Disease.Annals of neurology · 2026Article
- Deep brain stimulation of the nucleus basalis of Meynert in neurodegenerative diseases with cognitive impairment: An update on evidence and mechanisms.Neural regeneration research · 2026Article
- Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Automated Imaging Differentiation for Dementia: Including Alzheimer Disease Dementia and Dementia with Lewy Bodies.Neurology open access · 2026Article
- Microstructural changes in locus coeruleus-cortical projections in aged bonnet macaques are independent of myelin loss.Neurobiology of aging · 2026Article
- Subtype-Specific Brain Atrophy and White Matter Alterations in Mild Cognitive Impairment.Brain sciences · 2025Article
- Locus coeruleus-entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Advanced brain aging, selective vulnerability in gray matter, and cognition in Parkinson's disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Microstructural assessment of the locus coeruleus-entorhinal cortex pathway and association with ATN markers in cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Observational
- Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years.Molecular autism · 2025Article
- Targeting necroptosis in Alzheimer's disease: can exercise modulate neuronal death?Frontiers in aging neuroscience · 2025Review
- Locus Coeruleus Degeneration in Essential Tremor With Mild Cognitive Impairment: A Neuromelanin MRI Study.CNS neuroscience & therapeutics · 2025Article
- Free-water imaging of the nucleus basalis of Meynert in apolipoprotein E4 carriers.Frontiers in aging neuroscience · 2025Article
- Cognitive impairment and vulnerability of cholinergic brain network in the Alzheimer's continuum: free-water imaging based on diffusion tensor imaging.Frontiers in neuroscience · 2025Article
- Longitudinal Free-Water Changes in Dementia with Lewy Bodies.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- The Association among Hypothalamic Subnits, Gonadotropic and Sex Hormone Plasmas Levels in Alzheimer's Disease.Brain sciences · 2024Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Winston Thomas ChuFrom the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.ORCID 0000-0001-7818-9139
Wei-En WangFrom the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.
Laszlo ZaborszkyFrom the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.
Todd Eliot GoldeFrom the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.
Steven DeKoskyFrom the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.
Ranjan DuaraFrom the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.ORCID 0000-0001-8060-6309
David A LoewensteinFrom the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.
Malek AdjouadiFrom the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.
Stephen A CoombesFrom the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami.
David E VaillancourtFrom the J. Crayton Pruitt Family Department of Biomedical Engineering (W.T.C., D.E.V.), Department of Applied Physiology and Kinesiology (W.T.C., W.-e.W., S.A.C., D.E.V.), Department of Neuroscience (T.E.G.); Center for Translational Research in Neurodegenerative Diseases (T.E.G.), Department of Neurology (S.D., D.E.V.), and McKnight Brain Institute (S.D., D.E.V.), University of Florida, Gainesville; Center for Molecular and Behavioral Neuroscience (L.Z.), Rutgers University, Newark, NJ; Wein Center for Alzheimer's Disease and Memory Disorders (R.D., D.A.L.), Mount Sinai Medical Center, Miami Beach; Center for Cognitive Neuroscience and Aging (D.A.L.) and Department of Psychiatry and Behavioral Sciences (D.A.L.), University of Miami Miller School of Medicine; and Center for Advanced Technology and Education (M.A.), Florida International University, Miami. vcourt@ufl.edu.
Rutgers, The State University of New Jersey · US
Funding
Social Determinants of Health, Race/Ethnicity, and White Matter HyperintensitiesP30AG066506 · NIA · UNIVERSITY OF FLORIDA · PI Ranjan Duara, DAVID LOEWENSTEIN · 2020 to 2026
$25.6MUniversity of Florida - Mt. Sinai Medical Center AD Research CenterP50AG047266 · NIA · UNIVERSITY OF FLORIDA · PI FEBO, MARCELO · 2015 to 2019
$7.3MAFFERENT REGULATION OF CHOLINERGIC FOREBRAIN NEURONSR01NS023945 · NINDS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ZABORSZKY, LASZLO · 1986 to 2019
$6.5MRole of the Cortex and Cerebellum in Visually-Guided Motor BehaviorR01NS058487 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JAFFEE, MICHAEL S., VAILLANCOURT, DAVID E · 2008 to 2025
$6.1MScaling and Sequencing Motor Output in Humans: fMRI StudyR01NS052318 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VAILLANCOURT, DAVID E · 2005 to 2020
$6.0MAFFERENT REGULATION OF CHOLINERGIC FOREBRAIN NEURONSRF1NS023945 · NINDS · RUTGERS THE STATE UNIV OF NJ NEWARK · PI ZABORSZKY, LASZLO · 2020 to 2020
$2.9MInterdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8MNIA NIH HHS P30 AG066506NIA NIH HHS P50 AG047266NINDS NIH HHS R01 NS023945NINDS NIH HHS R01 NS052318NINDS NIH HHS R01 NS058487NINDS NIH HHS RF1 NS023945NINDS NIH HHS T32 NS082168
Abstract
BACKGROUND AND
objectivesThe goal of this work was to determine the relationship between diffusion microstructure and early changes in Alzheimer disease (AD) severity as assessed by clinical diagnosis, cognitive performance, dementia severity, and plasma concentrations of neurofilament light chain.
methodsDiffusion MRI scans were collected on cognitively normal participants (CN) and patients with early mild cognitive impairment (EMCI), late mild cognitive impairment, and AD. Free water (FW) and FW-corrected fractional anisotropy were calculated in the locus coeruleus to transentorhinal cortex tract, 4 magnocellular regions of the basal forebrain (e.g., nucleus basalis of Meynert), entorhinal cortex, and hippocampus. All patients underwent a battery of cognitive assessments; neurofilament light chain levels were measured in plasma samples.
resultsFW was significantly higher in patients with EMCI compared to CN in the locus coeruleus to transentorhinal cortex tract, nucleus basalis of Meynert, and hippocampus (mean Cohen DISCUSSION: These results show that higher FW is associated with greater clinical diagnosis severity, cognitive impairment, and neurofilament light chain. They also suggest that FW elevation occurs in the locus coeruleus to transentorhinal cortex tract, nucleus basalis of Meynert, and hippocampus in the transition from CN to EMCI, while other basal forebrain regions and the entorhinal cortex are not affected until a later stage of AD. FW is a clinically relevant and noninvasive early marker of structural changes related to cognitive impairment.
Indexed as
Alzheimer DiseaseBasal ForebrainCognitive DysfunctionBasal Nucleus of MeynertHumansLocus CoeruleusWaterWater
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