Evidence map›Paper›PMID 34906967›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2022

Air Pollution and Breast Cancer: An Examination of Modification By Underlying Familial Breast Cancer Risk.

Nicole M Niehoff, Mary Beth Terry, Deborah B Bookwalter, Joel D Kaufman, Katie M O'Brien, Dale P Sandler, Alexandra J White

Open access · bronzeAbstract read
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Ambient Air Pollution Exposure and Breast Cancer Risk Worldwide: A Systematic Review of Longitudinal Studies.International journal of environmental research and public health · 2024
    Pooled it
  2. Gene-Temperature Interactions and Risk of Childhood Acute Lymphoblastic Leukemia.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Air Pollution and Breast Cancer Incidence in the Multiethnic Cohort Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Nicole M NiehoffEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. nicole.niehoff@nih.gov.ORCID 0000-0002-5852-3010
Mary Beth TerryDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York and the Herbert Irving Comprehensive Cancer Center, New York, New York.
Deborah B BookwalterWestat, Durham, North Carolina.
Joel D KaufmanDepartment of Environmental and Occupational Health Sciences, Medicine, and Epidemiology, University of Washington, Seattle, Washington.ORCID 0000-0003-4174-9037
Katie M O'BrienEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.ORCID 0000-0002-1931-1349
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.ORCID 0000-0002-6776-0018
Alexandra J WhiteEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.ORCID 0000-0003-2455-2945
National Institute of Environmental Health Sciences · USNew York University · USUniversity of Washington · USWestat (United States) · US

Funding

XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
Environmental and Genetic Risk Factors For Breast Cancer: The Sister StudyZIAES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2025
$22.7M
Environment and Cancer EpidemiologyZIAES103332 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WHITE, ALEXANDRA · 2019 to 2025
$8.9M
Genetic and Environmental Risk Factors for Breast Cancer: The Sister StudyZ01ES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1999 to 2008
$1.3M
Intramural NIH HHS Z01 ES044005Intramural NIH HHS ZIA ES103332NIEHS NIH HHS P30 ES007033
6 · The paper itself

Abstract

backgroundAn increased familial risk of breast cancer may be due to both shared genetics and environment. Women with a breast cancer family history may have a higher prevalence of breast cancer-related gene variants and thus increased susceptibility to environmental exposures. We evaluated whether air pollutant and breast cancer associations varied by familial risk.

methodsSister Study participants living in the contiguous United States at enrollment (2003-2009;

resultsNO

conclusionsOur results provide additional evidence that air pollution may be implicated in breast cancer, particularly among women with a higher familial risk. IMPACT: Women at higher underlying breast cancer risk may benefit more from interventions to reduce exposure to NO

Indexed as

AdultAir PollutionBreast NeoplasmsEnvironmental ExposureFemaleHumansMiddle AgedNitrogen DioxideProspective StudiesRisk FactorsUnited StatesNitrogen Dioxide

Identifiers

PMID34906967
PMCPMC8825697
OpenAlexW4200220246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.