Trial reportContemporary clinical trials2022
Multiplicity adjustments in parallel-group multi-arm trials sharing a control group: Clear guidance is needed.
Trial report in Contemporary clinical trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Compression therapies for venous leg ulcers: The VENous Ulcer Study 6 (VenUS 6), an open, multicentre, randomised clinical trial.PLoS medicine · 2026Trial
- Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomised, quadruple-blind, parallel-group, phase 3 trial.The Lancet. Infectious diseases · 2023Trial
- Multilaboratory, Blinded, Randomized Trial of Five Cerebroprotectants in Ischemic Stroke.Circulation research · 2026Article
- A Multi-Stage Drop-the-Loser Design With Superiority Boundaries.Statistics in medicine · 2026Article
- Requirements for patient-reported outcomes and data analytics in health technology assessment in England, France and Germany, and the need for methods harmonization across European markets: a qualitative interview study.Journal of patient-reported outcomes · 2026Article
- Clinical Trial Simulation: Planning With the OCTAVE Framework, Implementation and Validation Principles.Statistics in medicine · 2026Article
- Review
- Review
- An efficient vaccine clinical trial: ACTG A5379 hepatitis B vaccine trial in persons with HIV.Vaccine · 2025Article
- An Epidemiologic Approach for Estimating Risk Reduction and Asymptotic Power on the Log-Difference Scale.International journal of environmental research and public health · 2025Article
- A Preplanned Multi-Stage Platform Trial for Discovering Multiple Superior Treatments With Control of FWER and Power.Biometrical journal. Biometrische Zeitschrift · 2025Article
- A gluten-free diet does not alter performance outcomes in nonceliac athletes undergoing sprint interval training: a pilot trial.Frontiers in sports and active living · 2025Article
- Association between COVID-19 severity and tobacco smoking status: a retrospective cohort study using propensity score matching weights analysis.BMJ open respiratory research · 2024Observational
- When should factorial designs be used for late-phase randomised controlled trials?Clinical trials (London, England) · 2024Review
- Statistical analysis plan for the motor neuron disease systematic multi-arm adaptive randomised trial (MND-SMART).Trials · 2023Article
- Design Considerations for a Phase II Platform Trial in Major Depressive Disorder.Pharmaceutical statisticsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Multi-arm, parallel-group clinical trials are an efficient way of testing several new treatments, treatment regimens or doses. However, guidance on the requirement for statistical adjustment to control for multiple comparisons (type I error) using a shared control group is unclear. We argue, based on current evidence, that adjustment is not always necessary in such situations. We propose that adjustment should not be a requirement in multi-arm, parallel-group trials testing distinct treatments and sharing a control group, and we call for clearer guidance from stakeholders, such as regulators and scientific journals, on the appropriate settings for adjustment of multiplicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.