ArticlePerioperative medicine (London, England)2021
Comparison of restrictive fluid therapy with goal-directed fluid therapy for postoperative delirium in patients undergoing spine surgery: a randomized controlled trial.
Article in Perioperative medicine (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The Impact of Individualized Hemodynamic Management on Intraoperative Fluid Balance and Hemodynamic Interventions during Spine Surgery in the Prone Position: A Prospective Randomized Trial.Medicina (Kaunas, Lithuania) · 2022Trial
- Prediction of postoperative pulmonary complications in geriatric patients with hip fracture using a nomogram incorporating bedside ultrasonography and clinical parameters.BMC geriatrics · 2026Observational
- Continuous Spinal Anesthesia in Frail Patients Undergoing Orthopedic Hip and Knee Revision Surgery: Advantages, Indications, and Risk Management-A Single-Center Retrospective Experience.Journal of clinical medicine · 2026Article
- A clinically useful nomogram integrating bedside lung ultrasound and clinical parameters for pulmonary complications after non-thoracic surgery in blunt chest trauma patients.Frontiers in medicine · 2026Article
- Regional Cerebral Oxygen Saturation and Risk of Delirium: A Systematic Review and Meta-Analysis.Diseases (Basel, Switzerland) · 2025Review
- Advances in research on the pathogenesis and signaling pathways associated with postoperative delirium (Review).Molecular medicine reports · 2025Review
- Smoking is a significant contributor to intraoperative blood loss in metastatic spinal tumor surgery: a propensity score analysis.BMC cancer · 2025Article
- Systematic review and meta-analysis of goal-directed haemodynamic therapy algorithms during surgery for the prevention of surgical site infection.EClinicalMedicine · 2024Article
- Nomogram for predicting the risk of postoperative delirium in elderly patients undergoing orthopedic surgery.Perioperative medicine (London, England) · 2024Article
- Article
- Perioperative Hemodynamic Optimization in Patients at Risk for Delirium - A Randomized-Controlled Trial.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostoperative delirium (POD) is a common phenomenon after spinal surgery. Intraoperative fluid management may affect POD. The aim of this study was to compare the effects of restrictive fluid therapy (RF) with those of goal-directed fluid therapy (GDT) on POD.
methodsA total of 195 patients aged ≥ 50 years who underwent spinal surgery were randomly divided into two groups: the RF group and the GDT group. In group RF, a bolus of lactated Ringer's solution was administered at a dose of 5 mL·kg
resultsThe incidence of POD was lower in the GDT group than in the RF group (12.4% vs 4.1%; P = 0.035) in the first 3 days after spine surgery. Compared to group RF, group GDT exhibited a significantly increased volume of intraoperative lactated Ringer's solution [1500 (interquartile range: 1128 to 1775) mL vs 1000 (interquartile range: 765 to 1300) mL, P < 0.001] and urine volume [398 (interquartile range: 288 to 600) mL vs 300 (interquartile range: 200 to 530) mL, P = 0.012]. Intraoperative MAP, CI and rSO
conclusionsGDT reduced the incidence of POD in middle- and old-aged patients undergoing spinal surgery possibly by stabilizing perioperative hemodynamic and improving the supply and demand of oxygen.
trial registrationChiCTR2000032603 ; Registered on May 3, 2020.
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