SynthesisJournal of cardiothoracic surgery2021
The effect of intraoperative dexmedetomidine on cognitive dysfunction after surgery: a updated meta-analysis.
Synthesis in Journal of cardiothoracic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy of perioperative dexmedetomidine in postoperative pain and neurocognitive functions in orthopedic surgery: a systematic review and meta-analysis with trial sequential analysis of randomized controlled trials.International journal of surgery (London, England) · 2025Pooled it
- Effects of anesthetic adjunctive agents on postoperative cognitive dysfunction in elderly patients undergoing noncardiac surgery: A Bayesian network meta-analysis.Brain and behavior · 2023Pooled it
- Trial
- Targeting Mitochondria for Postoperative Cognitive Dysfunction: From Mechanisms to Therapeutics.Molecular neurobiology · 2026Review
- Publication trends of dexmedetomidine and perioperative cognitive dysfunction: A bibliometric analysis from 1995 to 2024.Medicine · 2026Article
- Observational
- Effects of Dexmedetomidine Treatment After Cerebral Ischemia/Reperfusion on Apoptosis and Oxidative Stress: A Rat Model.Life (Basel, Switzerland) · 2026Article
- Transforaminal lumbar epidural injection of dexmedetomidine versus magnesium sulfate combined with dexamethasone for lower limb radicular pain management: a randomized, clinical trial.Anesthesia and pain medicine · 2025Article
- Effects of Midazolam and Dexmedetomidine on Cognitive Dysfunction Following Open-Heart Surgery: A Comprehensive Review.Brain and behavior · 2025Review
- Studies in rats of a target specific and reversible general anesthetic with a favorable safety profile.PloS one · 2025Article
- Anesthesia-related factors in the pathogenesis of postoperative cognitive dysfunction: a mechanistic perspective.Frontiers in neurology · 2025Article
- The clinical application progress of multimodal analgesia strategy in enhanced recovery after surgery: a narrative review.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Postoperative cognitive dysfunction: a concept analysis.Aging clinical and experimental research · 2024Review
- Effects of dexmedetomidine on renal function, inflammatory markers, and cognitive functioning in elderly patients undergoing hip replacement surgery.American journal of translational research · 2024Article
- Clinical Use of Adrenergic Receptor Ligands in Acute Care Settings.Handbook of experimental pharmacology · 2024Review
- A Survey on Enhanced Recovery After Surgery (ERAS) Elements in Cleft Palate Repair.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2023Article
- Comparison of the effects of remimazolam and dexmedetomidine on early postoperative cognitive function in elderly patients with gastric cancer.Frontiers in aging neuroscience · 2023Article
- General anesthesia vs. non-general anesthesia for elderly stroke patients treated with mechanical thrombectomy.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundPostoperative cognitive dysfunction (POCD) is one of the most common. Neuroprotective effects of dexmedetomidine (DEX) are reported in previous studies but evidence regarding the POCD is still unclear. In order to gain latest evidence, the present study analyzes the outcomes of randomized controlled trials (RCTs) which utilized DEX with general anaesthesia perioperatively.
methodFour online databases (PubMed, Embase, the Cochrane Library, and CNKI) were used to find relevant RCTs to conduct systematic analysis. All studies comparing the incidence of POCD or MMSE score between the DEX group and the placebo or comparator group in patients undergoing general anaesthetic surgery were eligible for inclusion. Based on the inclusion and exclusion criteria, the studies were selected. This meta-analysis was performed using odds ratios (ORs) with 95% confidence intervals (CIs) for dichotomous data and standardized mean difference (SMD) and 95% CIs for continuous data as effective measures.
resultsIn total of 21 studies were included in this meta-analysis. The results showed that the incidence of POCD in DEX group was significantly lower than the control group on the first (OR = 0.36, 95% CI 0.24-0.54),third (OR = 0.45,95% CI 0.33-0.61) and seventh (OR = 0.40,95% CI 0.26-0.60) postoperative days; the MMSE scores in DEX group were higher than the control group on the first (SMD = 1.24, 95% CI 1.08-1.41), third(SMD = 1.09, 95%CI 0.94-1.24) and seventh (SMD = 3.28, 95% CI 1.51-5.04) postoperative days.
conclusionsIntraoperative DEX use can ameliorate the POCD of patients who received surgical operations under general anesthesia, and effectively reduce the incidence of POCD and improve MMSE score.
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