Evidence map›Paper›PMID 34906057›Full record

ReviewCurrent topics in medicinal chemistry2022

Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives.

Shravan Kumar Uppulapu, Md Jahangir Alam, Santosh Kumar, Sanjay Kumar Banerjee

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Shravan Kumar UppulapuDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati 781101, India.
Md Jahangir AlamDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati 781101, India.
Santosh KumarDepartment of Cardiovascular Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Sanjay Kumar BanerjeeDepartment of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati 781101, India.
National Institute of Pharmaceutical Education and Research · INUniversity of Iowa · US

Funding

SUMO2-p66shc axis in vascular endothelial dysfunction and atherosclerosisR01HL152132 · NHLBI · UNIVERSITY OF IOWA · PI KUMAR, SANTOSH · 2020 to 2024
$2.1M
NHLBI NIH HHS R01 HL152132
6 · The paper itself

Abstract

Indazoles are a class of heterocyclic compounds with a bicyclic ring structure composed of a pyrazole ring and a benzene ring. Indazole-containing compounds with various functional groups have important pharmacological activities and can be used as structural motifs in designing novel drug molecules. Some of the indazole-containing molecules are approved by FDA and are already in the market. However, very few drugs with indazole rings have been developed against cardiovascular diseases. This review aims to summarize the structural and pharmacological functions of indazole derivatives which have shown efficacy against cardiovascular pathologies in experimental settings.

Indexed as

Cardiovascular DiseasesIndazolesHumansStructure-Activity RelationshipIndazolesCardiomyopathyCardiovascular diseasesDrug discoveryIndazole derivativesMolecular mechanismN. sativa

Identifiers

PMID34906057
PMCPMC10782885
OpenAlexW4200104526

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.