Evidence map›Paper›PMID 34905979›Full record

ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Diagnostic Accuracy of D-Dimers for Predicting Pulmonary Embolism in COVID-19-Patients.

Falmata Laouan Brem, Boudouh Asmae, Yassine Amane, Mohammed-Amine Bouazzaoui, Miri Chaymae, Hammam Rasras, Siham Nasri, Naima Abda, Imane Skiker, Hatim Kouismi and 3 more

Abstract read
In one paragraph

Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Department.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Falmata Laouan BremDepartment of Cardiology, 470522Mohammed VI University Hospital, Mohammed First University, Oujda, MAR, Morocco.ORCID https://orcid.org/0000-0002-5742-0781
Boudouh AsmaeDepartment of Pneumology, 470522Mohammed VI University Hospital, Mohammed First University, Oujda, MAR, Morocco.
Yassine AmaneDepartment of Radiology, 470522Mohammed VI University Hospital, Mohammed First University, Oujda, MAR, Morocco.
Mohammed-Amine BouazzaouiEpidemiological Laboratory of Clinical Research and Public Health, Mohammed First University, Oujda, MAR, Morocco.
Miri ChaymaeDepartment of Cardiology, 470522Mohammed VI University Hospital, Mohammed First University, Oujda, MAR, Morocco.ORCID https://orcid.org/0000-0002-3752-0953
Hammam RasrasDepartment of Cardiology, 470522Mohammed VI University Hospital, Mohammed First University, Oujda, MAR, Morocco.
Siham NasriDepartment of Radiology, 470522Mohammed VI University Hospital, Mohammed First University, Oujda, MAR, Morocco.
Naima AbdaEpidemiological Laboratory of Clinical Research and Public Health, Mohammed First University, Oujda, MAR, Morocco.
Imane SkikerDepartment of Radiology, 470522Mohammed VI University Hospital, Mohammed First University, Oujda, MAR, Morocco.
Hatim KouismiDepartment of Pneumology, 470522Mohammed VI University Hospital, Mohammed First University, Oujda, MAR, Morocco.
Bazid ZakariaDepartment of Cardiology, 470522Mohammed VI University Hospital, Mohammed First University, Oujda, MAR, Morocco.
Nabila IsmailiDepartment of Cardiology, 470522Mohammed VI University Hospital, Mohammed First University, Oujda, MAR, Morocco.
Noha El OuafiDepartment of Cardiology, 470522Mohammed VI University Hospital, Mohammed First University, Oujda, MAR, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceProinflammatory and hypercoagulable states with marked elevation seen in D-Dimer levels have been accurately described in patients infected by the SARS- Cov2 even without pulmonary embolism (PE).

objectivesTo compare D-dimers values in patients infected by the novel Coronavirus 2019 (COVID-19) with and without PE and to establish an optimal D-dimer cut-off to predict the occurrence of PE, which guides pulmonary computed tomography angiography (CTPA) indication.

methodsWe retrospectively enrolled all COVID-19-patients admitted between October first and November 22th, 2020, at the University Hospital Center of Mohammed VI, Oujda (Morocco), suspected to have PE and underwent a CTPA. Demographic characteristics and blood test results were compared between PE-positive and PE-negative. The receiver operating characteristics (ROC) curve was constructed to establish an optimal D-Dimer cut-off to predict the occurrence of PE.

resultsThe study population consisted of 84 confirmed COVID-19-patients. The mean age was 64.93 years (SD 14.19). PE was diagnosed on CTPA in 31 (36.9%) patients. Clinical symptoms and in-hospital outcomes were similar in both groups except that more men had PE (

conclusionA D-dimer cut-off value of 2600 ng/mL is a significant predictor of PE in COVID-19-patients with a sensitivity of 90.3%.

Indexed as

AgedCOVID-19FemaleFibrin Fibrinogen Degradation ProductsHumansMaleMiddle AgedPulmonary EmbolismRetrospective StudiesSARS-CoV-2Fibrin Fibrinogen Degradation Productsfibrin fragment DcoagulopathyCOVID-19d-dimerspulmonary embolismthreshold

Identifiers

PMID34905979
PMCPMC8689602

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.