Evidence map›Paper›PMID 34905954›Full record

ArticleHypertension (Dallas, Tex. : 1979)2022

Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association.

Vesna D Garovic, Ralf Dechend, Thomas Easterling, S Ananth Karumanchi, Suzanne McMurtry Baird, Laura A Magee, Sarosh Rana, Jane V Vermunt, Phyllis August, American Heart Association Council on Hypertension; Council on the Kidney in Cardiovascular Disease, Kidney in Heart Disease Science Committee; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Peripheral Vascular Disease; and Stroke Council

Erratum issued 2 registry-linked trialsAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 288 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
288citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06353256 nacompletednot on this mapstarted 2024, after this paper: background citation

Alabama Womb 2 Heart Solution (AW2H): A Community Health Worker Intervention to Improve Short- and Long-term Outcomes in Black Patients With Adverse Pregnancy Outcomes

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2024 to 2025Enrolled61ConditionsPreeclampsia Postpartum, Adverse Pregnancy OutcomesArmsusual postpartum care, usual postpartum care + community health worker intervention
NCT06859359 narecruitingnot on this mapstarted 2024, after this paper: background citation

Improving Maternal Cardiovascular Outcomes Through the Implementation of a Hypertensive Disorders of Pregnancy Bundle in Nigeria

TypeinterventionalSponsorWashington University School of MedicineRan2024 to 2029Enrolled1,200ConditionsHypertensive Disorder of PregnancyArmsHypertension Disorders of Pregnancy (HDP) Implementation Bundle
3 · Its place in the literature

Who cites it

288 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Hemodynamics-guided treatment of hypertensive disorders of pregnancy: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Pooled it
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  6. Guideline
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  9. Trial
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  14. Hypertension Management in Pregnancy and Postpartum.Journal of the American Society of Nephrology : JASN · 2026
    Review
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  18. Review
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228 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Vesna D Garovic
Ralf Dechend
Thomas Easterling
S Ananth Karumanchi
Suzanne McMurtry Baird
Laura A Magee
Sarosh Rana
Jane V Vermunt
Phyllis August
American Heart Association Council on Hypertension; Council on the Kidney in Cardiovascular Disease, Kidney in Heart Disease Science Committee; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Peripheral Vascular Disease; and Stroke Council

Funding

Hypertensive pregnancy disorders and future coronary artery diseaseR01HL136348 · NHLBI · MAYO CLINIC ROCHESTER · PI GAROVIC, VESNA D · 2018 to 2022
$2.6M
NHLBI NIH HHS R01 HL136348
6 · The paper itself

Abstract

Hypertensive disorders of pregnancy (HDP) remain one of the major causes of pregnancy-related maternal and fetal morbidity and mortality worldwide. Affected women are also at increased risk for cardiovascular disease later in life, independently of traditional cardiovascular disease risks. Despite the immediate and long-term cardiovascular disease risks, recommendations for diagnosis and treatment of HDP in the United States have changed little, if at all, over past decades, unlike hypertension guidelines for the general population. The reasons for this approach include the question of benefit from normalization of blood pressure treatment for pregnant women, coupled with theoretical concerns for fetal well-being from a reduction in utero-placental perfusion and in utero exposure to antihypertensive medication. This report is based on a review of current literature and includes normal physiological changes in pregnancy that may affect clinical presentation of HDP; HDP epidemiology and the immediate and long-term sequelae of HDP; the pathophysiology of preeclampsia, an HDP commonly associated with proteinuria and increasingly recognized as a heterogeneous disease with different clinical phenotypes and likely distinct pathological mechanisms; a critical overview of current national and international HDP guidelines; emerging evidence that reducing blood pressure treatment goals in pregnancy may reduce maternal severe hypertension without increasing the risk of pregnancy loss, high-level neonatal care, or overall maternal complications; and the increasingly recognized morbidity associated with postpartum hypertension/preeclampsia. Finally, we discuss the future of research in the field and the pressing need to study socioeconomic and biological factors that may contribute to racial and ethnic maternal health care disparities.

Indexed as

American Heart AssociationAntihypertensive AgentsBlood PressureFemaleHumansHypertension, Pregnancy-InducedPregnancyUnited StatesAntihypertensive AgentsAHA Scientific Statementscardiovascular diseasesdiagnosishypertensionpregnancytherapeutics

Identifiers

PMID34905954
PMCPMC9031058

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.