Evidence map›Paper›PMID 34905700›Full record

ArticleOpen biology2021

Comparative transcriptome analysis and CRISPR/Cas9 gene editing reveal that E4BP4 mediates lithium upregulation of

Qin Zhou, Kankan Wang, Jiameng Qiu, Di Zhu, Tian Tian, Yunfei Zhang, Ximing Qin

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Open biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. The crosstalk between CREB and PER2 mediates the transition between mania- and depression-like behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qin ZhouDepartment of Health Sciences, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui Province 230601, People's Republic of China.
Kankan WangDepartment of Health Sciences, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui Province 230601, People's Republic of China.
Jiameng QiuDepartment of Health Sciences, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui Province 230601, People's Republic of China.
Di ZhuDepartment of Health Sciences, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui Province 230601, People's Republic of China.
Tian TianDepartment of Health Sciences, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui Province 230601, People's Republic of China.
Yunfei ZhangModern Experiment Technology Center, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui Province 230601, People's Republic of China.
Ximing QinDepartment of Health Sciences, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui Province 230601, People's Republic of China.ORCID 0000-0003-2496-2434
Anhui University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bipolar disorder (BPD) is a psychiatric disorder characterized by alternate episodes of mania and depression. Disruption of normal circadian clock and abnormal sleep cycles are common symptoms of BPD patients. Lithium salt is currently an effective clinical therapeutic drug for BPD. Animal and cellular studies have found that lithium salt can upregulate the expression of the clock gene

Indexed as

AnimalsBasic-Leucine Zipper Transcription FactorsBipolar DisorderCell LineCRISPR-Cas SystemsCycloheximideGene EditingGene Expression ProfilingGene Expression RegulationHumansLithiumMiceMutagenesis, Site-DirectedNIH 3T3 CellsPeriod Circadian ProteinsPromoter Regions, GeneticBasic-Leucine Zipper Transcription FactorsCycloheximideLithiumNFIL3 protein, humanNfil3 protein, mousePER2 protein, humanPer2 protein, mousePeriod Circadian Proteinsbipolar disordercircadian clockcrispr/cas9lithiumPer2 expression

Identifiers

PMID34905700
PMCPMC8670960
OpenAlexW4200284263

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.