Evidence map›Paper›PMID 34905386›Full record

ArticleScience signaling2021

Aberrant Ca

Ekin Guney, Ana Paula Arruda, Günes Parlakgul, Erika Cagampan, Nina Min, Grace Yankun Lee, Lily Greene, Eva Tsaousidou, Karen Inouye, Myoung Sook Han and 2 more

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025
    Pooled it
  2. Junctophilin-2-orchestrated calcium signalosome regulates brown adipocyte thermogenesis and energy metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. CabioRxiv : the preprint server for biology · 2026
    Article
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  13. Autophagy in Hepatic Steatosis: A Structured Review.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Ekin GuneySabri Ülker Center for Metabolic Research and Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-7050-0831
Ana Paula ArrudaSabri Ülker Center for Metabolic Research and Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-6179-2687
Günes ParlakgulSabri Ülker Center for Metabolic Research and Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-9365-7287
Erika CagampanSabri Ülker Center for Metabolic Research and Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Nina MinSabri Ülker Center for Metabolic Research and Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-7881-2514
Grace Yankun LeeSabri Ülker Center for Metabolic Research and Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Lily GreeneSabri Ülker Center for Metabolic Research and Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0001-9428-2456
Eva TsaousidouSabri Ülker Center for Metabolic Research and Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Karen InouyeSabri Ülker Center for Metabolic Research and Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-2743-2121
Myoung Sook HanProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.ORCID 0000-0002-7226-2590
Roger J DavisProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.ORCID 0000-0002-0130-1652
Gökhan S HotamisligilSabri Ülker Center for Metabolic Research and Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-2906-1897
University of Massachusetts Chan Medical School · USBroad Institute · US

Funding

TRAINING GRANT IN ACADEMIC ENDOCRINOLOGYT32DK007529 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Ursula B. Kaiser, Anand Vaidya · 1986 to 2026
$6.3M
Adipose Tissue Metabolic Stress ResponsesR01DK112698 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2017 to 2025
$4.4M
Metabolic Stress SignalingR01DK107220 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2016 to 2023
$3.6M
NIDDK NIH HHS R01 DK107220NIDDK NIH HHS R01 DK112698NIDDK NIH HHS T32 DK007529
6 · The paper itself

Abstract

Chronic metabolic inflammation is a key feature of obesity, insulin resistance, and diabetes. Here, we showed that altered regulation of the Ca

Indexed as

AdipocytesObesityHumansInflammationSignal Transduction

Identifiers

PMID34905386
PMCPMC10130146
OpenAlexW4200007723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.