Evidence map›Paper›PMID 34905304›Full record

ArticleStatistical applications in genetics and molecular biology2021

Batch effect reduction of microarray data with dependent samples using an empirical Bayes approach (BRIDGE).

Qing Xia, Jeffrey A Thompson, Devin C Koestler

Abstract read
In one paragraph

Article in Statistical applications in genetics and molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Statistical applications in genetics and molecular biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qing XiaDepartment of Biostatistics & Data Science, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.
Jeffrey A ThompsonDepartment of Biostatistics & Data Science, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.
Devin C KoestlerDepartment of Biostatistics & Data Science, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
UNDERSTANDING THE ROLE OF SMALL RNAS IN ARABIDOPSIS POLLEN DEVELOPMENTP20RR016475 · NCRR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI LUSHINGTON, GERALD H · 2001 to 2011
$38.1M
Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Kalyani Pyaram, Steven Allan Soper · 2019 to 2026
$21.5M
NCI NIH HHS P30 CA168524NCRR NIH HHS P20 RR016475NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

Batch-effects present challenges in the analysis of high-throughput molecular data and are particularly problematic in longitudinal studies when interest lies in identifying genes/features whose expression changes over time, but time is confounded with batch. While many methods to correct for batch-effects exist, most assume independence across samples; an assumption that is unlikely to hold in longitudinal microarray studies. We propose

Indexed as

Gene Expression ProfilingResearch DesignBayes TheoremLongitudinal StudiesMicroarray Analysisbatch effect correctionCOMBATlongitudinal gene expressiontemporal microarray data

Identifiers

PMID34905304
PMCPMC9617207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.