Evidence map›Paper›PMID 34905155›Full record

ReviewHead and neck pathology2022

NUT Carcinoma of the Submandibular Gland: A Case at This Uncommon Site with Review of the Literature.

Vanessa Moreno, Christopher A French, Tianhua Guo, Hui Zhu, Songling Zhang, Darryl Duncan, Ron J Karni, Angel I Blanco, Syed H Jafri, Karan Saluja

Open access · greenAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Head and neck pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. NUT carcinoma of the submandibular gland: A case report.Cancer reports (Hoboken, N.J.) · 2023
    Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Vanessa MorenoDepartment of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, TX, 77030, Houston, USA.
Christopher A FrenchDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Tianhua GuoDepartment of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, TX, 77030, Houston, USA.
Hui ZhuDepartment of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, TX, 77030, Houston, USA.
Songling ZhangDepartment of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, TX, 77030, Houston, USA.
Darryl DuncanDepartment of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, TX, 77030, Houston, USA.
Ron J KarniDepartment of Otorhinolaryngology-Head and Neck Surgery, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Angel I BlancoDepartment of Neurosurgery, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Syed H JafriDivision of Oncology, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Karan SalujaDepartment of Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, 6431 Fannin Street, TX, 77030, Houston, USA. karan.saluja@uth.tmc.edu.ORCID http://orcid.org/0000-0002-2844-5234
The University of Texas Health Science Center at Houston · USBrigham and Women's Hospital · USThe University of Texas Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nuclear protein in testis (NUT) carcinoma is a rare, highly aggressive, undifferentiated carcinoma that harbors a characteristic rearrangement of the NUTM1 gene. The majority arise in adolescents and young adults especially from the midline structures of the thorax, head, and neck. Until the present, there have only been three reported cases of NUT carcinoma of the submandibular gland, two of which were reported in children and another one in an adult from Korea. Here, we report the first case of NUT carcinoma arising in the submandibular gland of an adult female in the United States, representing the fourth case worldwide. A fine needle aspiration and biopsy was performed, and the diagnosis was confirmed by NUT immunohistochemical staining and fusion of the BRD4 (19p13.12) and NUTM1 (15q14) gene loci by fluorescence in-situ hybridization on the resection specimen. Salivary gland is an unusual site for NUT carcinoma and is rarely described in submandibular gland. We reviewed the clinicopathologic features of this entity at this site along with role of NUTM1 gene rearrangements in NUT tumorigenesis.

Indexed as

CarcinomaNuclear ProteinsAdolescentAdultBiopsy, Fine-NeedleBromodomain Containing ProteinsCell Cycle ProteinsChildFemaleHumansMaleNeoplasm ProteinsOncogene Proteins, FusionSubmandibular GlandTranscription FactorsYoung AdultBRD4 protein, humanBromodomain Containing ProteinsCell Cycle ProteinsNeoplasm ProteinsNuclear ProteinsOncogene Proteins, FusionTranscription FactorsBRD4-NUTM1NUT carcinomaNUTM1NUT midline carcinomaSalivary glandSubmandibular gland

Identifiers

PMID34905155
PMCPMC9424374
OpenAlexW4200051325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.