ArticleEJNMMI research2021
Amyloid PET quantification using low-dose CT-guided anatomic standardization.
Article in EJNMMI research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Low-dose CT for MRI-free quantification of tau PET in Alzheimer's disease: a multicentre, cross-sectional, comparison study.The Lancet medical imaging & theranostics · 2026Article
- Performance of CT-guided spatial normalization for semi-quantification of dopamine transporter SPECT and detection of nigrostriatal degeneration.Annals of nuclear medicine · 2026Article
- Effect of magnetic resonance image-based motion correction on the centiloid scale: a comparison with and without correction.Annals of nuclear medicine · 2026Article
- Amyloid PET quantification with deep learning segmentation models without MRI.EJNMMI physics · 2026Article
- Comparison of MRI-, CT- and PET-based anatomical standardization for Centiloid scale calculation in [Annals of nuclear medicine · 2026Article
- Comparison of consistency in centiloid scale among different analytical methods in amyloid PET: the CapAIBL, VIZCalc, and Amyquant methods.Annals of nuclear medicine · 2024Article
- Deep Learning-Driven Estimation of Centiloid Scales from Amyloid PET Images withBrain sciences · 2024Article
- Development of software for measuring brain amyloid accumulation usingBrain and behavior · 2023Article
- Non-standard pipeline without MRI has replicability in computation of Centiloid scale values for PiB andNeuroimage. Reports · 2022Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCentiloid (CL) scaling has become a standardized quantitative measure in amyloid PET because it facilitates the direct comparison of results across institutions, even when different analytical methods or tracers are used. Standard volumes of interest must be used to calculate the CL scale after the anatomic standardization of amyloid PET images using coregistered MRI; if the MRI is unavailable, the CL scale cannot be accurately calculated. This study sought to determine the substitutability of low-dose CT, which is used to correct PET attenuation in PET/CT equipment, by evaluating the measurement accuracy when low-dose CT is used as an alternative to MRI in the calculation of the CL scale. Amyloid PET images obtained using
trial registrationJapan Registry of Clinical Trials, jRCTs031180321 (registered 18 March 2019, https://jrct.niph.go.jp/latest-detail/jRCTs031180321 ).
resultsA Bland-Altman plot showed that CL
conclusionsLow-dose CT of PET/CT can substitute for MRI in the anatomic standardization used to calculate the CL scale from amyloid PET, although a slight underestimation occurs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.