ArticleThe Journal of nutrition2022
Biomarker-Based Methods and Study Designs to Calibrate Dietary Intake for Assessing Diet-Disease Associations.
Article in The Journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Metabolomics-Based Biomarker for Dietary Fat and Associations with Chronic Disease Risk in Postmenopausal Women.The Journal of nutrition · 2023Trial
- Carbon Isotope Ratios of Plasma and RBC Fatty Acids Identify Meat Consumers in a 12-Week Inpatient Feeding Study of 32 Men.The Journal of nutrition · 2023Trial
- Biomarkers for dietary fatty acid densities among postmenopausal United States females derived using a habitual-diet human feeding study.The American journal of clinical nutrition · 2026Article
- Micronutrient Biomarker Selection and Assay Methods and Performance in Double-Blind, Randomized, Controlled Micronutrient Dose Response (MiNDR) Trials among Women of Reproductive Age and Pregnant Women in Rural Bangladesh.Current developments in nutrition · 2025Article
- Vitamin Status and Risk of Age-Related Diseases Among Adult Residents of the Pearl River Delta Region.Nutrients · 2025Article
- Metabolomics signatures of sweetened beverages and added sugar are related to anthropometric measures of adiposity in young individuals: results from a cohort study.The American journal of clinical nutrition · 2024Article
- USING SIMULTANEOUS REGRESSION CALIBRATION TO STUDY THE EFFECT OF MULTIPLE ERROR-PRONE EXPOSURES ON DISEASE RISK UTILIZING BIOMARKERS DEVELOPED FROM A CONTROLLED FEEDING STUDY.The annals of applied statistics · 2024Article
- Measuring diet by metabolomics: a 14-d controlled feeding study of weighed food intake.The American journal of clinical nutrition · 2024Article
- Metabolomics Biomarkers for Fatty Acid Intake and Biomarker-Calibrated Fatty Acid Associations with Chronic Disease Risk in Postmenopausal Women.The Journal of nutrition · 2023Article
- Urinary Sucrose and Fructose From Spot Urine May Be Used as a Predictive Biomarker of Total Sugar Intake-Findings From a Controlled Feeding Study.The Journal of nutrition · 2023Article
- Biomarkers for Components of Dietary Protein and Carbohydrate with Application to Chronic Disease Risk in Postmenopausal Women.The Journal of nutrition · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDietary biomarkers measured in biospecimens can play an important role in correcting for random and systematic measurement error in self-reported nutrient intake when assessing diet-disease associations. To date, high-quality biomarkers for calibrating self-reported dietary intake have only been developed for a few nutrients.
objectivesTo investigate new study designs and regression calibration approaches for calibrating self-reported nutrient intake for use in disease association analyses.
methodsWe studied 3 regression calibration approaches: 1) an existing approach built on a calibration cohort assuming the existence of an objective biomarker (i.e., biomarker with random independent measurement error), 2) a proposed approach using a biomarker development cohort, and 3) a proposed 2-stage approach using both cohorts. We conducted simulation studies to compare the performance of different study designs/methods for estimating diet-disease associations and applied suitable methods to examine the association of sodium and potassium intake with cardiovascular disease (CVD) risk in Women's Health Initiative cohorts.
resultsSimulation studies showed that the first approach can lead to biased association estimation when the objective biomarker assumption is violated; the second and third proposed approaches obviate the need for such an objective biomarker. Precision for estimating the association depends critically on sample size of the biomarker development cohort and the strength of the self-reported nutrient intake. Analyses based on the second and third approaches support previously reported significant findings using the first approach about associations of the ratio of sodium to potassium intake with CVD risk while providing efficiency gain for some outcomes.
conclusionsSelf-reported dietary intake needs to be calibrated for measurement error correction in diet-disease association analyses. When there are no existing objective biomarkers that can be used for calibration purpose, controlled feeding studies can be used to develop new biomarkers for use in calibration or can be used to calibrate self-reported dietary intake directly.
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