Evidence map›Paper›PMID 34904960›Full record

ArticleAging2021

Titanium dioxide nanoparticles perturb the blood-testis barrier via disruption of actin-based cell adhesive function.

Dong-Qi Ni, Dan-Dan Ma, Shuang-Li Hao, Wan-Xi Yang, Tamas Kovacs, Fu-Qing Tan

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Therapeutic effect ofRSC advances · 2025
    Article
  2. MyD88 Signaling in Sertoli Cells Mediates LPS-Induced Orchitis in Mice.Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Article
  3. Article
  4. Is Emerging Nanomedicine a Friend or Foe to Germ Cells?International journal of nanomedicine · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Dong-Qi NiThe Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Dan-Dan MaThe Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Shuang-Li HaoThe Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Wan-Xi YangThe Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Tamas KovacsDepartment of Obstetrics and Gynaecology, Faculty of Medicine, University of Debrecens, Debrecen 4032, Hungary.
Fu-Qing TanThe First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China.
Zhejiang University · CNUniversity of Debrecen · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As one of the most commonly used nanoparticles, titanium dioxide nanoparticles (TiO

Indexed as

ActinsAnimalsBlood-Testis BarrierCell AdhesionCell LineDose-Response Relationship, DrugMaleMetal NanoparticlesMiceSertoli CellsTight Junction ProteinsTitaniumActinsTight Junction ProteinsTitaniumtitanium dioxideactinblood-testis barriertight junctionTiO2-NPsTM-4 cell

Identifiers

PMID34904960
PMCPMC8714145
OpenAlexW4200117732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.