ArticleThe Journal of clinical investigation1986
Interleukin 1 stimulates granulocyte macrophage colony-stimulating activity release by vascular endothelial cells.
Article in The Journal of clinical investigation, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 275 citations in OpenAlex.
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- Quantitative Proteome Responses to Oncolytic Reovirus in GM-CSF- and M-CSF-Differentiated Bone Marrow-Derived Cells.Journal of proteome research · 2020Article
- Inflammatory extracellular vesicles prompt heart dysfunction via TRL4-dependent NF-κB activation.Theranostics · 2020Article
- Granulocyte-Macrophage Colony-Stimulating Factor as a Therapeutic Target in Multiple Sclerosis.Neurology and therapy · 2019Review
- Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage.Journal of leukocyte biology · 2016Review
- A Review of GM-CSF Therapy in Sepsis.Medicine · 2015Review
- Mavrilimumab: an evidence based review of its potential in the treatment of rheumatoid arthritis.Core evidence · 2014Review
- Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination.Journal of the neurological sciences · 2013Review
- Article
- Clinical role of GM-CSF in neutrophil recovery in relation to health care parameters.Medical oncology (Northwood, London, England) · 1996Review
- Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cells.The Journal of cell biology · 1996Article
- Adhesion-independent synergy of monocytes and endothelial cells in cytokine production: regulation of IL-6 and GM-CSF production by PAF.Mediators of inflammation · 1996Article
- Species-specific metastasis of human tumor cells in the severe combined immunodeficiency mouse engrafted with human tissue.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Comparison of peripheral blood leukocyte kinetics after live Escherichia coli, endotoxin, or interleukin-1 alpha administration. Studies using a novel interleukin-1 receptor antagonist.Annals of surgery · 1993Article
- Early circulating erythroid progenitors (BFU-E) in sickle cell anemia.Experientia · 1993Review
- Effects of endotoxin-associated protein on hematopoiesis.Infection and immunity · 1992Article
- Synthesis of IL-1 alpha and IL-1 beta by arterial cells in atherosclerosis.The American journal of pathology · 1991Article
- Expression of ras oncogenes in cultured human cells alters the transcriptional and posttranscriptional regulation of cytokine genes.The Journal of clinical investigation · 1990Article
- Interleukin 1 receptor blockade attenuates the host inflammatory response.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- A role for protein kinase C activity in interleukin-1 (IL-1) induction of IL-2 gene expression but not in IL-1 signal transduction.Molecular and cellular biology · 1990Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Studies designed to characterize monocyte-derived recruiting activity (MRA) a monokine that stimulates endothelial cells to produce granulocyte macrophage-colony-stimulating activity (CSA) by endothelial cells, show that it is a thermolabile protein of from 12,000 to 24,000 D which, on chromatofocusing, shows three separate peaks of eluted activity from pH 7.5 to 5.0. Because these and many other properties of MRA are identical to those of interleukin 1 (IL-1), we tested the hypothesis that MRA and IL-1 are identical. We cultured vascular endothelial cells with various concentrations of purified native and recombinant IL-1 (pI 7 form), then tested the endothelial cell supernatants for GM-CSA. Purified native IL-1 and recombinant IL-1 stimulated endothelial cells to release CSA. The MRA of native IL-1, recombinant IL-1, and unfractionated monocyte conditioned medium was neutralized by a highly specific rabbit anti-human IL-1 antiserum. Chromatofocusing fractions that contained MRA contained immunoreactive IL-1 on immunoblotting and the bioactivity was neutralized completely by treatment with the antiserum. We conclude that IL-1 induces the release of CSA by vascular endothelial cells, that IL-1 is constitutively produced by monocytes in vitro, and that MRA and IL-1 are biologically, biophysically and, immunologically identical.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.