Evidence map›Paper›PMID 34904939›Full record

ArticleThe Journal of general virology2021

Physiological magnesium concentrations increase fidelity of diverse reverse transcriptases from HIV-1, HIV-2, and foamy virus, but not MuLV or AMV.

Ruofan Wang, Ashton T Belew, Vasudevan Achuthan, Najib El Sayed, Jeffrey J DeStefano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Fidelity of DNA ligase I is sensitive to physiological MgThe Journal of biological chemistry · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ruofan WangDepartment of Cell Biology and Molecular Genetics, Bioscience Research Building, University of Maryland, College Park, Maryland 20742, USA.
Ashton T BelewDepartment of Cell Biology and Molecular Genetics, Bioscience Research Building, University of Maryland, College Park, Maryland 20742, USA.
Vasudevan AchuthanDepartment of Cell Biology and Molecular Genetics, Bioscience Research Building, University of Maryland, College Park, Maryland 20742, USA.
Najib El SayedDepartment of Cell Biology and Molecular Genetics, Bioscience Research Building, University of Maryland, College Park, Maryland 20742, USA.
Jeffrey J DeStefanoDepartment of Cell Biology and Molecular Genetics, Bioscience Research Building, University of Maryland, College Park, Maryland 20742, USA.
Bioscience Research · US

Funding

Biochemistry of HIV reverse transcriptase fidelity and inhibitor interactionsR01AI150480 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI DESTEFANO, JEFFREY J · 2019 to 2019
$294k
NIAID NIH HHS R01 AI150480
6 · The paper itself

Abstract

Reverse transcriptases (RTs) are typically assayed using optimized Mg

Indexed as

DNA, ViralDrug Resistance, ViralMagnesiumMutationMutation RateRetroviridaeRNA-Directed DNA PolymeraseDNA, ViralMagnesiumRNA-Directed DNA Polymerasefidelitymagnesiummutation rateretrovirusreverse transcriptase

Identifiers

PMID34904939
PMCPMC10019084
OpenAlexW4226079958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.