Evidence map›Paper›PMID 34904911›Full record

ArticlePharmaceutical biology2022

Efficacy of Yougui pill combined with Buzhong Yiqi decoction in alleviating the sexual dysfunction in female rats through modulation of the gut microbiota.

Yangyun Wang, Chaoliang Shi, Wandong Yu, Wei Jiao, Guowei Shi

Open access · goldAbstract readComparative Study
In one paragraph

Article in Pharmaceutical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Improvement of Menopausal Symptoms byFood science & nutrition · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yangyun WangDepartment of Urology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Chaoliang ShiDepartment of Urology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Wandong YuDepartment of Urology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Wei JiaoDepartment of Urology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Guowei ShiDepartment of Urology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextYougui pill combined with Buzhong Yiqi decoction (YPBYD) is used to relieve sexual dysfunction in clinical practice.

objectiveTo investigate changes in microbial composition caused by sexual dysfunction and identify dominant bacteria related to YPBYD treatment. MATERIALS AND

methodsFemale Sprague-Dawley rats were randomly divided into four groups (

resultsAfter YPBYD treatment, the levels of E2 and cAMP in OVX rats significantly increased (E2: from 20.45 ± 1.60 ng/L to 24.38 ± 1.70 ng/L; cAMP: from 261.41 ± 9.21 pg/mL to 373.75 ± 17.37 pg/mL). OVX treatment decreased diversity of gut microbiota and YPBYD treatment restored gut microbiota composition. Compared with Sham group, the abundance of DISCUSSION AND

conclusionsThese findings are the first to indicate YPBYD can alleviate female sexual dysfunction by modulating gut microbiota in OVX rats, which will help enhance the understanding on potential mechanism of YPBYD against sexual dysfunction.

Indexed as

AnimalsCyclic AMPDrugs, Chinese HerbalEstradiolFemaleGastrointestinal MicrobiomeOvariectomyRatsRats, Sprague-DawleyRNA, Ribosomal, 16SSexual Dysfunction, PhysiologicalCyclic AMPDrugs, Chinese HerbalEstradiolestradiol 3-benzoateRNA, Ribosomal, 16Syougui16S rRNA sequencingELISAovariectomized ratSexual functiontraditional Chinese medicine

Identifiers

PMID34904911
PMCPMC8676705
OpenAlexW4200057091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.