Evidence map›Paper›PMID 34904858›Full record

ArticleMolecular pain

Heparan sulfate 3-

Seii Ohka, Souichi Yamada, Daisuke Nishizawa, Yoshiko Fukui, Hideko Arita, Kazuo Hanaoka, Masako Iseki, Jitsu Kato, Setsuro Ogawa, Ayako Hiranuma and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Synthetic biology for heparin biomanufacturing.Bioresources and bioprocessing · 2026
    Review
  2. Detection by Single-Cell RNA Sequencing of Virally Mediated Skin Diseases.JID innovations : skin science from molecules to population health · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Seii OhkaAddictive Substance Project, 13931Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID 0000-0003-2394-6440
Souichi YamadaDepartment of Virology I, 13511National Institute of Infectious Diseases, Tokyo, Japan.
Daisuke NishizawaAddictive Substance Project, 13931Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Yoshiko FukuiDepartment of Virology I, 13511National Institute of Infectious Diseases, Tokyo, Japan.
Hideko AritaDepartment of Anesthesiology and Pain Relief Center, 13622JR Tokyo General Hospital, Tokyo, Japan.ORCID 0000-0002-4151-5962
Kazuo HanaokaDepartment of Anesthesiology and Pain Relief Center, 13622JR Tokyo General Hospital, Tokyo, Japan.
Masako IsekiDepartment of Anesthesiology and Pain Medicine, 175793Juntendo University School of Medicine, Tokyo, Japan.
Jitsu KatoDepartment of Anesthesiology, 38113Nihon University School of Medicine, Tokyo, Japan.
Setsuro OgawaNihon University University Research Center, Tokyo, Japan.
Ayako HiranumaAddictive Substance Project, 13931Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Shinya KasaiAddictive Substance Project, 13931Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Junko HasegawaAddictive Substance Project, 13931Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Masakazu HayashidaAddictive Substance Project, 13931Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Shuetsu FukushiDepartment of Virology I, 13511National Institute of Infectious Diseases, Tokyo, Japan.
Masayuki SaijoDepartment of Virology I, 13511National Institute of Infectious Diseases, Tokyo, Japan.
And Kazutaka IkedaAddictive Substance Project, 13931Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID 0000-0001-8342-0278
National Institute of Infectious Diseases · JPTokyo Metropolitan Institute of Medical Science · JPJR Tokyo General Hospital · JPJuntendo University · JPNihon University · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pain that is associated with herpes zoster (HZ) can become long-lasting neuropathic pain, known as chronic post-herpetic neuralgia (PHN), especially in the elderly. HZ is caused by the reactivation of latent varicella-zoster virus (VZV), whereas PHN is not attributed to ongoing viral replication. Although VZV infection reportedly induces neuronal cell fusion in humans, the pathogenesis of PHN is not fully understood. A genome-wide association study (GWAS) revealed significant associations between PHN and the rs12596324 single-nucleotide polymorphism (SNP) of the heparan sulfate 3-

Indexed as

Herpes ZosterNeuralgia, PostherpeticGenome-Wide Association StudyHerpesvirus 3, HumanHumansSulfotransferasesheparitin sulfotransferaseSulfotransferasesfusogenic activityglycoproteinsheparan sulfate 3-O-sulfotransferase 4herpes zosterneuropathic painpost-herpetic neuralgiasingle-nucleotide polymorphismvaricella-zoster virus

Identifiers

PMID34904858
PMCPMC8733353
OpenAlexW4200229128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.