Evidence map›Paper›PMID 34904415›Full record

ArticleJournal of Zhejiang University. Science. B2021

ERα promotes transcription of tumor suppressor gene

Bingjie Wang, Yinghui Shen, Tianyu Liu, Li Tan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Apolipoproteins: New players in cancers.Frontiers in pharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Bingjie WangCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Yinghui ShenCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Tianyu LiuColorectal Cancer Center, Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Li TanCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. litan@fudan.edu.cn.
Fudan University · CNPudong Medical Center · CN

Funding

the National Key R&D Project of China 2016YFA0101800 to Li TANthe National Natural Science Foundation of China 81672785, 31871291 and 82073113 to Li TAN
6 · The paper itself

Abstract

Apolipoprotein A-I (ApoA-I), the main protein component of high-density lipoprotein (HDL), plays a pivotal role in reverse cholesterol transport (RCT). Previous studies indicated a reduction of serum ApoA-I levels in various types of cancer, suggesting ApoA-I as a potential cancer biomarker. Herein, ectopically overexpressed ApoA-I in MDA-MB-231 breast cancer cells was observed to have antitumor effects, inhibiting cell proliferation and migration. Subsequent studies on the mechanism of expression regulation revealed that estradiol (E2)/estrogen receptor α (ERα) signaling activates

Indexed as

Tumor MicroenvironmentAcetylationApolipoprotein A-IBreast NeoplasmsCell Line, TumorChromatinE1A-Associated p300 ProteinEstrogen Receptor alphaExonsFemaleGenes, Tumor SuppressorHistonesHumansApolipoprotein A-IChromatinE1A-Associated p300 ProteinEP300 protein, humanESR1 protein, humanEstrogen Receptor alphaHistonesAcetylation of histone 3 lysine 27 (H3K27ac)Apolipoprotein A-I (ApoA-I)Breast cancerEstrogen receptor α (ERα)p300

Identifiers

PMID34904415
PMCPMC8669322
OpenAlexW4200094408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.