Evidence map›Paper›PMID 34904400›Full record

ArticleFEBS open bio2022

The HIF-1α pathway plays a critical role in salivary gland development in ex vivo organ cultures.

Tomomasa Kimura, Manabu Sakai, Nao Gojo, Mikio Watanabe, Narikazu Uzawa, Takayoshi Sakai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tomomasa KimuraDepartment of Oral-facial Disorders, Osaka University Graduate School of Dentistry, Suita, Japan.
Manabu SakaiDepartment of Clinical Laboratory, Osaka University Dental Hospital, Suita, Japan.ORCID 0000-0003-0403-6994
Nao GojoDepartment of Oral-facial Disorders, Osaka University Graduate School of Dentistry, Suita, Japan.
Mikio WatanabeDepartment of Clinical Laboratory and Biomedical Sciences, Osaka University Graduate School of Medicine, Suita, Japan.ORCID 0000-0001-5971-9296
Narikazu UzawaDepartment of Oral and Maxillofacial Surgery 2, Osaka University Graduate School of Dentistry, Suita, Japan.
Takayoshi SakaiDepartment of Oral-facial Disorders, Osaka University Graduate School of Dentistry, Suita, Japan.ORCID 0000-0003-4348-4896
The University of Osaka · JPOsaka University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcription factor, hypoxia-inducible factor-1α (HIF-1α), has previously been shown to upregulate the expression of hypoxia-related genes, including erythropoietin (EPO). However, the role of hypoxia-inducible factor-1α in morphogenesis during salivary gland development is unclear. We investigated the function of HIF-1α in submandibular gland (SMG) organ cultures obtained from embryonic day 13.5 embryos from ICR female mice. Expression of HIF-1α, glucose transporter 1, and vascular endothelial growth factor was induced under hypoxia (5% O

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitVascular Endothelial Growth Factor AAnimalsFemaleMiceMice, Inbred ICROrgan Culture TechniquesSalivary GlandsHypoxia-Inducible Factor 1, alpha SubunitVascular Endothelial Growth Factor AdevelopmentHIF-1αhypoxiasalivary glands

Identifiers

PMID34904400
PMCPMC8804608
OpenAlexW4200138065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.