Evidence map›Paper›PMID 34904391›Full record

ReviewImmunity, inflammation and disease2022

Estimating the within-subject (CV

Birthe R Skarbø, Erik W Vinnes, Tore Wentzel-Larsen, Marit S Sylte, Torunn O Apelseth

Abstract readReview
In one paragraph

Review in Immunity, inflammation and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Estimating the within-subject (CVImmunity, inflammation and disease · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Birthe R SkarbøDepartment of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.ORCID 0000-0002-6856-7017
Erik W VinnesDepartment of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
Tore Wentzel-LarsenCentre for Clinical Research, Haukeland University Hospital, Bergen, Norway.
Marit S SylteDepartment of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
Torunn O ApelsethDepartment of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTryptase is used as a biomarker to support the diagnosis of anaphylaxis and hematologic diseases. In the event of a mast cell activation during anaphylaxis, a temporary increase in the concentration of tryptase may be seen. On the basis of clinical studies, an increase of 2 µg/L + 20% from basis level has been proposed as significant. To evaluate the increase in tryptase levels, the within-subject (CV

methodsBlood samples were collected from healthy volunteers once a week consecutively over a 10-week period. Tryptase was measured by the use of a fluoroenzyme immunoassay (ImmunoCAP

resultsFourteen presumably healthy young adults (six males and eight females, age 23-35 years) were included. The CV

conclusionsYoung healthy adults without ongoing allergic reactions show low within-subject biological variation. Higher biological variation was observed between subjects.

Indexed as

TryptasesAdultBiomarkersFemaleHealthy VolunteersHumansMaleReference ValuesYoung AdultBiomarkersTryptasesbiological variationreference change valuetryptase

Identifiers

PMID34904391
PMCPMC8959422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.