Evidence map›Paper›PMID 34904376›Full record

ReviewJournal of cellular and molecular medicine2022

The atomic portrait of SARS-CoV-2 as captured by cryo-electron microscopy.

Tudor Emanuel Fertig, Leona Chitoiu, George Terinte-Balcan, Victor-Eduard Peteu, Daciana Marta, Mihaela Gherghiceanu

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. The atomic portrait of SARS-CoV-2 as captured by cryo-electron microscopy.Journal of cellular and molecular medicine · 2022
    Review
  8. Is diabetes a real susceptibility for SARS-CoV-2 oral manifestation?Journal of oral and maxillofacial pathology : JOMFP
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tudor Emanuel FertigUltrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania.ORCID 0000-0003-0251-3865
Leona ChitoiuUltrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania.
George Terinte-BalcanUltrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania.
Victor-Eduard PeteuUltrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania.
Daciana MartaUltrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania.
Mihaela GherghiceanuUltrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania.ORCID 0000-0001-6117-4328
Institutul National Victor Babes · ROCarol Davila University of Medicine and Pharmacy · RO

Funding

Ministerul Cercetării şi Inovării PN19.29.01.02/2019Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii PN-III-P1-1.2-PCCDI-2017-0529
6 · The paper itself

Abstract

Transmission electron microscopy has historically been indispensable for virology research, as it offers unique insight into virus function. In the past decade, as cryo-electron microscopy (cryo-EM) has matured and become more accessible, we have been able to peer into the structure of viruses at the atomic level and understand how they interact with the host cell, with drugs or with antibodies. Perhaps, there was no time in recent history where cryo-EM was more needed, as SARS-CoV-2 has spread around the globe, causing millions of deaths and almost unquantifiable economic devastation. In this concise review, we aim to mark the most important contributions of cryo-EM to understanding the structure and function of SARS-CoV-2 proteins, from surface spikes to the virus core and from virus-receptor interactions to antibody binding.

Indexed as

Angiotensin-Converting Enzyme 2Antibodies, ViralCOVID-19COVID-19 VaccinesCryoelectron MicroscopyEpitopesHumansModels, MolecularProtein BindingProtein Interaction Domains and MotifsProtein Structure, SecondaryReceptors, VirusSARS-CoV-2Serine EndopeptidasesSpike Glycoprotein, CoronavirusVirionACE2 protein, humanAngiotensin-Converting Enzyme 2Antibodies, ViralCOVID-19 VaccinesEpitopesReceptors, VirusSerine EndopeptidasesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2TMPRSS2 protein, humanCOVID-19cryo-electron microscopycryo-electron tomographySARS-CoV-2single-particle analysisstructural biology

Identifiers

PMID34904376
PMCPMC8742239
OpenAlexW4200618461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.