ArticleJournal of clinical hypertension (Greenwich, Conn.)2022
Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- The association between the triglyceride-glucose index and serum uric acid: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- The Association Between the Triglyceride Glucose Index and Hyperuricemia: A Dose-Response Meta-Analysis.Nutrients · 2025Pooled it
- The mediating role of obesity in the relationship between sleep duration and depressive symptoms: A population-based cross-sectional study.Metabolism open · 2026Article
- Association Between Triglyceride-Glucose Index and Hyperuricemia in Hospitalized Patients with Depression: A Cross-Sectional Study.Neuropsychiatric disease and treatment · 2026Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and gout in US adults: a cross-sectional study of the mediating role of BMI.Diabetology & metabolic syndrome · 2025Article
- TyG-WC Index as a Superior Predictor of Hyperuricemia Risk in the Hypertensive Population: A Prospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Muscle quality index and hyperuricemia: adipose tissue as a mediator.Frontiers in endocrinology · 2025Article
- Association Between Triglyceride-Glucose Index and Gout in Young Adults in China.International journal of general medicine · 2025Article
- Correlation between logFrontiers in endocrinology · 2025Article
- Association between the triglyceride-glucose index and hyperuricemia: potential role of obesity in patients with Type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
- The association between triglyceride-glucose index combined with obesity indicators and stroke risk: A longitudinal study based on CHARLS data.BMC endocrine disorders · 2024Article
- The association between triglyceride glucose index and gout: a cross-sectional analysis based on NHANES 2007-2018.BMC endocrine disorders · 2024Article
- Insulin Resistance Surrogates May Predict HTN-HUA in Young, Non-Obese Individuals.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Article
- Sex-Based Differences in the Associations Between Obesity- and Lipid-Related Indexes and Hyperuricemia Risk in Patients with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Triglyceride-glucose index as a marker of adverse cardiovascular prognosis in patients with coronary heart disease and hypertension.Cardiovascular diabetology · 2023Observational
- Insulin resistance surrogate markers and risk of hyperuricemia among patients with and without coronary artery disease: a cross-sectional study.Frontiers in nutrition · 2023Article
- Mediation effect of obesity on the association between triglyceride-glucose index and hyperuricemia in Chinese hypertension adults.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The triglyceride glucose (TyG) index was regarded as a simple surrogate marker of insulin resistance (IR). It is confirmed that IR was significantly associated with hyperuricemia, and obesity was the risk factor for IR and hyperuricemia. However, the relationship between the TyG index and hyperuricemia and the potential role of obesity in Han Chinese hypertension are not entirely elucidated. A community-based cross-sectional study was conducted in 4551 hypertension patients aged 40-75 years with clinical and biochemical data. The TyG index was calculated as ln [fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2]. Hyperuricemia was determined as serum uric acid ≥357μmol/L (6 mg/dl) for females and ≥417μmol/L (7 mg/dl) for males. Our study suggested that the TyG index was higher in patients with hyperuricemia than in those without (8.99±0.61, 8.70±0.59, p < .001). The prevalence of hyperuricemia in patients with the lowest (≤8.32), second (8.33-8.66), third (8.67-9.07) and the highest quartile (≥9.08) of the TyG index was 6.0%, 10.4%, 15.4%, 21.4%, respectively. Logistic regression analysis suggested that the higher quartile of TyG index was associated with increased hyperuricemia risk whether in crude or adjusted models (p < .05). Mediation analysis showed that all of our obesity indexes partially mediated the association between the TyG index and hyperuricemia to some extent. In Conclusions, the TyG index is significantly associated with hyperuricemia in hypertension patients among Han Chinese, obesity plays a partial mediation role in this relationship.
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