ArticleNMR in biomedicine2022
Evaluation of enzymatic proteoglycan loss and collagen degradation in human articular cartilage using ultrashort echo time-based biomarkers: A feasibility study.
Article in NMR in biomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Ultrashort echo time quantitative magnetization transfer MRI detects non-enzymatic crosslinking of collagen in ex vivo rat bones.JBMR plus · 2026Article
- Spatial charge-hydrophobicity configuration modulates cationic peptide transport in cartilage.Biophysical journal · 2025Article
- A feasibility study of in vivo quantitative ultra-short echo time-MRI for detecting early cartilage degeneration.Insights into imaging · 2024Article
- Dynamics of γ-aminobutyric acid concentration in the human brain in response to short visual stimulation.Magma (New York, N.Y.) · 2024Article
- The effect of cartilage dehydration and rehydration on quantitative ultrashort echo time biomarkers.Quantitative imaging in medicine and surgery · 2023Article
- Preliminary study on the assessment of early cartilage degeneration by quantitative ultrashort echo time magnetic resonance imagingQuantitative imaging in medicine and surgery · 2022Article
- Articular Cartilage Assessment Using Ultrashort Echo Time MRI: A Review.Frontiers in endocrinology · 2022Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The objective of the current study was to investigate the feasibility of quantitative 3D ultrashort echo time (UTE)-based biomarkers in detecting proteoglycan (PG) loss and collagen degradation in human cartilage. A total of 104 cartilage samples were harvested for a trypsin digestion study (n = 44), and a sequential trypsin and collagenase digestion study (n = 60), respectively. Forty-four cartilage samples were randomly divided into a trypsin digestion group (tryp group) and a control group (phosphate-buffered saline [PBS] group) (n = 22 for each group) for the trypsin digestion experiment. The remaining 60 cartilage samples were divided equally into four groups (n = 15 for each group) for sequential trypsin and collagenase digestion, including PBS + Tris (incubated in PBS, then Tris buffer solution), PBS + 30 U col (incubated in PBS, then 30 U/ml collagenase [30 U col] with Tris buffer solution), tryp + 30 U col (incubated in trypsin solution, then 30 U/ml collagenase with Tris buffer solution), and tryp + Tris (incubated in trypsin solution, then Tris buffer solution). The 3D UTE-based MRI biomarkers included T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.