Evidence map›Paper›PMID 34904226›Full record

ArticleBritish journal of pharmacology2022

Crosstalk between epithelial sodium channels (ENaC) and basolateral potassium channels (K

Elena Isaeva, Ruslan Bohovyk, Mykhailo Fedoriuk, Alexey Shalygin, Christine A Klemens, Adrian Zietara, Vladislav Levchenko, Jerod S Denton, Alexander Staruschenko, Oleg Palygin

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Epithelial NaComprehensive Physiology · 2024
    Review
  7. Article
  8. Article
  9. KAmerican journal of physiology. Renal physiology · 2023
    Article
  10. The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023
    Review
  11. Kir5.1 channels: potential role in epilepsy and seizure disorders.American journal of physiology. Cell physiology · 2022
    Review
  12. Inward rectifier potassium (Kir) channels in the retina: living our vision.American journal of physiology. Cell physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Elena IsaevaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Ruslan BohovykDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Mykhailo FedoriukDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Alexey ShalyginDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Christine A KlemensDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Adrian ZietaraDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Vladislav LevchenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jerod S DentonDepartment of Anesthesiology and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alexander StaruschenkoDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-5190-8356
Oleg PalyginDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-3680-5527
Medical College of Wisconsin · USMedical University of South Carolina · USVanderbilt University Medical Center · US

Funding

ZONISMIDE IN THE TREATMENT OF SEIZURES IN PATIENTSM01RR000058 · NCRR · MEDICAL COLLEGE OF WISCONSIN · PI HYDE, JAMES F · 1985 to 2006
$19.9M
Training in Signature Transdisciplinary Cardiovascular SciencesT32HL134643 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Justin L Grobe, Jacquelyn P Kulinski · 2017 to 2026
$4.2M
Renal ion channels in the control of blood pressureR35HL135749 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI STARUSCHENKO, ALEXANDER · 2017 to 2023
$3.6M
Role of basolateral K channels in renal salt handling and BP controlR01DK126720 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PALYGIN, OLEG · 2021 to 2024
$1.5M
Development of Distal Nephron Diuretics Targeting Kir4.1/5.1 Heteromeric Potassium ChannelsR01DK120821 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENTON, JEROD S. · 2019 to 2021
$1.2M
The Role of CIC-6 in Vascular Control of Blood PressureK99HL153686 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI KLEMENS, CHRISTINE ANNE · 2021 to 2022
$201k
Essential role of Kir4.1/Kir5.1 channels in renal salt handling and blood pressure controlR56DK121750 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI PALYGIN, OLEG · 2019 to 2019
$92k
Transport and metabolism in the kidneyI01BX004024 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI STARUSCHENKO, ALEXANDER · 2019 to 2025
–
BLRD VA I01 BX004024NCRR NIH HHS M01 RR000058NHLBI NIH HHS K99 HL153686NHLBI NIH HHS R35 HL135749NHLBI NIH HHS T32 HL134643NIDDK NIH HHS R01 DK120821NIDDK NIH HHS R01 DK126720NIDDK NIH HHS R56 DK121750
6 · The paper itself

Abstract

background and purposeInwardly rectifying K EXPERIMENTAL APPROACH: The effect of fluoxetine, amitriptyline and recently developed K KEY

resultsWe found that inhibition of K CONCLUSION AND IMPLICATIONS: The present data uncover a specific role of the K

Indexed as

Kidney Tubules, CollectingPotassium Channels, Inwardly RectifyingAmitriptylineAnimalsCricetinaeCricetulusElectrolytesEpithelial Sodium ChannelsRatsRats, Inbred DahlSodiumAmitriptylineElectrolytesEpithelial Sodium ChannelsPotassium Channels, Inwardly RectifyingSodiumamitriptylineENaChypokalaemiaKcnj10Kcnj16Kir (IRK) channels

Identifiers

PMID34904226
PMCPMC9106811
OpenAlexW4200453832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.