Evidence map›Paper›PMID 34904217›Full record

ArticleHistology and histopathology2022

GPBAR1 promotes proliferation and is related to poor prognosis of high-grade glioma via inducing MAFB expression.

Suohui Sun, Hui Guo, Nan Liang, Tao Wu, Chunpu Zhang, Huaqing Li

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Article in Histology and histopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Suohui SunDepartment of Neurosurgery, the Second Hospital of Shandong First Medical University, Taian, Shandong, China.
Hui GuoDepartment of Pediatrics, Central Hospital of Taian, Taian, Shandong, China.
Nan LiangDepartment of Neurosurgery, the Second Hospital of Shandong First Medical University, Taian, Shandong, China.
Tao WuDepartment of Neurosurgery, the Second Hospital of Shandong First Medical University, Taian, Shandong, China.
Chunpu ZhangDepartment of Neurosurgery, the Second Hospital of Shandong First Medical University, Taian, Shandong, China.
Huaqing LiDepartment of Intensive Care Unit, the Second Hospital of Shandong First Medical University, Taian, Shandong, China. lxicjn315dcj@163.com.
Second Hospital of Shandong University · CNAffiliated Hospital of Taishan Medical University · CNTaian City Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlioma is the most prevalent brain tumors with extremely poor prognosis, but the prognostic biomarkers of high-grade (grade III and IV) gliomas (HGG) are still insufficient. MATERIALS AND

methodsIn our study, we investigated the expression of GPBAR1 in HGG by qRT-PCR and immunohistochemistry (IHC), and evaluated the clinical significance of GPBAR1 with univariate and multivariate analyses. By retrieving the data from TCGA, we screened the genes significantly associated with GPBAR1, and identified the correlation between GPBAR1 and MAFB. By experiments in vitro, we showed the pivotal role of MAFB in GPBAR1-induced proliferation of HGG.

resultsGPBAR1 expression in HGGs was significantly higher than that in normal brain tissues. GPBAR1 was an independent prognostic biomarker of HGG. GPBAR1 promoted the proliferation of HGG by inducing MAFB expression. MAFB was also a prognostic biomarker of HGG, and patients with co-expression of MAFB and GPBAR1 had worse prognosis.

conclusionsGPBAR1 promoted the proliferation of HGG by inducing MAFB expression. Both GPBAR1 and MAFB were prognostic biomarkers of HGG, and patients with co-expression of MAFB and GPBAR1 had worse prognosis than those with only GPBAR1 or MAFB expression.

Indexed as

Brain NeoplasmsGliomaMafB Transcription FactorReceptors, G-Protein-CoupledBiomarkersCell ProliferationHumansNeoplasm GradingPrognosisBiomarkersGPBAR1 protein, humanMAFB protein, humanMafB Transcription FactorReceptors, G-Protein-Coupled

Identifiers

PMID34904217
OpenAlexW4226193698

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.